ArrayXPath

|PathMeSH |Pathway mapping |Help |ChromoViz |Registration |Contact us

ArrayXPath has searched   #pathways #nodes (non-redundant) #nodes (redundant) BioCarta 277 1260 7646

ArrayXPath has identified 139 (12.50%) out of 1112 input elements in the following pathways

Source # pathways # identified nodes # total nodes BioCarta 209 127 3651

Set FDR cut off

Cluster 1 has 63 gene products

ArrayXPath has identified 12 out of 63 input elements in 27 out of 277 BioCarta pathways.

Clusters BioCarta 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50

Pathway Identified node p-value q-value BioCarta//Mn_Platelet Amyloid Precursor Protein Pathway      1/14 (15) 0.1358 0.1571 BioCarta//Mn_Regulators of Bone Mineralization      1/10 (55) 0.0989 0.1571 BioCarta//Mn_Vitamin C in the Brain      1/11 (22) 0.1082 0.1571 BioCarta//Mn_Inhibition of Matrix Metalloproteinases      1/9 (15) 0.0894 0.1571 BioCarta//Mn_g-Secretase mediated ErbB4 Signaling Pathway      1/8 (20) 0.0798 0.1571 BioCarta//Mn_Presenilin action in Notch and Wnt signaling      1/14 (31) 0.1358 0.1571 BioCarta//Mn_Proteolysis and Signaling Pathway of Notch      1/6 (20) 0.0604 0.1571 BioCarta//Mn_Stress Induction of HSP Regulation      1/14 (22) 0.1358 0.1571 BioCarta//Mn_The PRC2 Complex sets Long-term gene Silencing The Modification of Histone Tails      1/13 (21) 0.1267 0.1571 BioCarta//Mn_Regulation of hematopoiesis by cytokines      1/14 (40) 0.1358 0.1571 BioCarta//Mn_T Cytotoxic Cell Surface Molecules      1/14 (14) 0.1358 0.1571 BioCarta//Mn_IL 17 Signaling Pathway      1/15 (16) 0.1448 0.1577 BioCarta//Mn_Regulation of transcriptional activity by PML      1/17 (25) 0.1626 0.1672 BioCarta//Mn_Angiotensin-converting enzyme 2 regulates heart function      1/13 (34) 0.1267 0.2132 BioCarta//Mn_Extrinsic Prothrombin Activation Pathway      1/13 (24) 0.1267 0.2132 BioCarta//Mn_Phospholipids as signalling intermediaries      1/25 (42) 0.2303 0.2244 BioCarta//Mn_FAS signaling pathway ( CD95 )      1/28 (32) 0.2544 0.2355 BioCarta//Mn_BCR Signaling Pathway      1/33 (52) 0.2930 0.2583 BioCarta//Mn_p38 MAPK Signaling Pathway      1/37 (39) 0.3225 0.2596 BioCarta//Mn_Agrin in Postsynaptic Differentiation      1/37 (47) 0.3225 0.2596 BioCarta//Mn_The role of FYVE-finger proteins in vesicle transport      1/6 (34) 0.0604 0.2798 BioCarta//Mn_Ca++/ Calmodulin-dependent Protein Kinase Activation      1/6 (41) 0.0604 0.2798 BioCarta//Mn_Keratinocyte Differentiation      1/46 (67) 0.3848 0.2899 BioCarta//Mn_NFAT and Hypertrophy of the heart (Transcription in the broken heart)      1/47 (77) 0.3914 0.2899 BioCarta//Mn_HIV-I Nef: negative effector of Fas and TNF      1/56 (76) 0.4478 0.3189 BioCarta//Mn_MAPKinase Signaling Pathway      1/82 (85) 0.5849 0.4011 BioCarta//Mn_Intrinsic Prothrombin Activation Pathway      2/23 (36) 0.0220 0.4075

Cluster 2 has 14 gene products but doesn't match to BioCarta pathways

Cluster 3 has 23 gene products

ArrayXPath has identified 1 out of 23 input elements in 3 out of 277 BioCarta pathways.

Clusters BioCarta 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50

Pathway Identified node p-value q-value BioCarta//Mn_SODD/TNFR1 Signaling Pathway      1/10 (18) 0.0079 0.0162 BioCarta//Mn_TNFR1 Signaling Pathway      1/28 (35) 0.0222 0.0227 BioCarta//Mn_HIV-I Nef: negative effector of Fas and TNF      1/56 (76) 0.0444 0.0303

Cluster 4 has 8 gene products

ArrayXPath has identified 1 out of 8 input elements in 1 out of 277 BioCarta pathways.

Clusters BioCarta 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50

Pathway Identified node p-value q-value BioCarta//Mn_Dicer Pathway      1/2 (7) 0.0016 0.0016

Cluster 5 has 27 gene products

ArrayXPath has identified 4 out of 27 input elements in 9 out of 277 BioCarta pathways.

Clusters BioCarta 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50

Pathway Identified node p-value q-value BioCarta//Mn_Phosphorylation of MEK1 by cdk5/p35 down regulates the MAP kinase pathway      1/13 (17) 0.0407 0.0594 BioCarta//Mn_Trka Receptor Signaling Pathway      1/13 (13) 0.0407 0.0594 BioCarta//Mn_Regulators of Bone Mineralization      1/10 (55) 0.0314 0.0594 BioCarta//Mn_Extrinsic Prothrombin Activation Pathway      1/13 (24) 0.0407 0.0594 BioCarta//Mn_Nerve growth factor pathway (NGF)      1/19 (41) 0.0590 0.0718 BioCarta//Mn_Intrinsic Prothrombin Activation Pathway      1/23 (36) 0.0711 0.0741 BioCarta//Mn_Erk1/Erk2 Mapk Signaling pathway      1/29 (34) 0.0890 0.0812 BioCarta//Mn_Nuclear Receptors in Lipid Metabolism and Toxicity      1/33 (40) 0.1008 0.0818 BioCarta//Mn_Multi-Drug Resistance Factors      1/6 (14) 0.0189 0.1382

Cluster 6 has 3 gene products

ArrayXPath has identified 1 out of 3 input elements in 5 out of 277 BioCarta pathways.

Clusters BioCarta 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50

Pathway Identified node p-value q-value BioCarta//Mn_Bioactive Peptide Induced Signaling Pathway      1/33 (50) 0.0262 0.0213 BioCarta//Mn_Rac 1 cell motility signaling pathway      1/22 (24) 0.0175 0.0213 BioCarta//Mn_Rho cell motility signaling pathway      1/27 (29) 0.0214 0.0213 BioCarta//Mn_Erk and PI-3 Kinase Are Necessary for Collagen Binding in Corneal Epithelia      1/22 (40) 0.0175 0.0237 BioCarta//Mn_mCalpain and friends in Cell motility      1/21 (37) 0.0167 0.0679

Cluster 7 has 28 gene products

ArrayXPath has identified 3 out of 28 input elements in 5 out of 277 BioCarta pathways.

Clusters BioCarta 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50

Pathway Identified node p-value q-value BioCarta//Mn_Nuclear Receptors in Lipid Metabolism and Toxicity      2/33 (40) 0.0020 0.0061 BioCarta//Mn_Pelp1 Modulation of Estrogen Receptor Activity      1/6 (10) 0.0142 0.0221 BioCarta//Mn_Downregulated of MTA-3 in ER-negative Breast Tumors      1/21 (29) 0.0492 0.0306 BioCarta//Mn_Estrogen-responsive protein Efp controls cell cycle and breast tumors growth      1/15 (56) 0.0353 0.0306 BioCarta//Mn_Role of ERBB2 in Signal Transduction and Oncology      1/21 (34) 0.0492 0.0306

Cluster 8 has 17 gene products

ArrayXPath has identified 1 out of 17 input elements in 1 out of 277 BioCarta pathways.

Clusters BioCarta 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50

Pathway Identified node p-value q-value BioCarta//Mn_CDK Regulation of DNA Replication      1/15 (52) 0.0119 0.0119

Cluster 9 has 19 gene products

ArrayXPath has identified 2 out of 19 input elements in 11 out of 277 BioCarta pathways.

Clusters BioCarta 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50

Pathway Identified node p-value q-value BioCarta//Mn_AKT Signaling Pathway      1/20 (30) 0.0315 0.0259 BioCarta//Mn_cdc25 and chk1 Regulatory Pathway in response to DNA damage      1/9 (13) 0.0142 0.0259 BioCarta//Mn_Cell Cycle: G2/M Checkpoint      1/23 (25) 0.0362 0.0259 BioCarta//Mn_RB Tumor Suppressor/Checkpoint Signaling in response to DNA damage      1/13 (17) 0.0205 0.0259 BioCarta//Mn_Regulation of BAD phosphorylation      1/21 (30) 0.0331 0.0259 BioCarta//Mn_Regulation of PGC-1a      1/17 (23) 0.0268 0.0259 BioCarta//Mn_Role of nicotinic acetylcholine receptors in the regulation of apoptosis      1/15 (24) 0.0237 0.0259 BioCarta//Mn_The information-processing pathway at the IFN-beta enhancer      1/11 (19) 0.0174 0.0259 BioCarta//Mn_Control of skeletal myogenesis by HDAC & calcium/calmodulin-dependent kinase (CaMK)      1/27 (39) 0.0424 0.0276 BioCarta//Mn_Multiple antiapoptotic pathways from IGF-1R signaling lead to BAD phosphorylation      1/15 (29) 0.0237 0.0283 BioCarta//Mn_Signal Dependent Regulation of Myogenesis by Corepressor MITR      1/8 (24) 0.0127 0.0908

Cluster 10 has 21 gene products

ArrayXPath has identified 2 out of 21 input elements in 2 out of 277 BioCarta pathways.

Clusters BioCarta 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50

Pathway Identified node p-value q-value BioCarta//Mn_The IGF-1 Receptor and Longevity      1/14 (14) 0.0221 0.0113 BioCarta//Mn_IL-10 Anti-inflammatory Signaling Pathway      1/12 (16) 0.0190 0.0194

Cluster 11 has 16 gene products

ArrayXPath has identified 3 out of 16 input elements in 9 out of 277 BioCarta pathways.

Clusters BioCarta 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50

Pathway Identified node p-value q-value BioCarta//Mn_Deregulation of CDK5 in Alzheimers Disease      1/10 (16) 0.0236 0.0277 BioCarta//Mn_Lissencephaly gene (LIS1) in neuronal migration and development      1/15 (34) 0.0353 0.0277 BioCarta//Mn_Phosphorylation of MEK1 by cdk5/p35 down regulates the MAP kinase pathway      1/13 (17) 0.0307 0.0277 BioCarta//Mn_Reelin Signaling Pathway      1/7 (10) 0.0166 0.0277 BioCarta//Mn_Regulation of ck1/cdk5 by type 1 glutamate receptors      1/16 (37) 0.0376 0.0277 BioCarta//Mn_Shuttle for transfer of acetyl groups from mitochondria to the cytosol      1/8 (11) 0.0189 0.0277 BioCarta//Mn_Intrinsic Prothrombin Activation Pathway      1/23 (36) 0.0538 0.0308 BioCarta//Mn_Rac 1 cell motility signaling pathway      1/22 (24) 0.0515 0.0308 BioCarta//Mn_Malate-aspartate shuttle      1/3 (6) 0.0071 0.0368

Cluster 12 has 19 gene products

ArrayXPath has identified 2 out of 19 input elements in 40 out of 277 BioCarta pathways.

Clusters BioCarta 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50

Pathway Identified node p-value q-value BioCarta//Mn_Agrin in Postsynaptic Differentiation      1/37 (47) 0.0579 0.0373 BioCarta//Mn_Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling      1/32 (42) 0.0502 0.0373 BioCarta//Mn_Bioactive Peptide Induced Signaling Pathway      1/33 (50) 0.0517 0.0373 BioCarta//Mn_CXCR4 Signaling Pathway      1/24 (35) 0.0377 0.0373 BioCarta//Mn_Fc Epsilon Receptor I Signaling in Mast Cells      1/37 (47) 0.0579 0.0373 BioCarta//Mn_fMLP induced chemokine gene expression in HMC-1 cells      1/34 (55) 0.0533 0.0373 BioCarta//Mn_How Progesterone Initiates the Oocyte Maturation      1/29 (31) 0.0455 0.0373 BioCarta//Mn_Human Cytomegalovirus and Map Kinase Pathways      1/16 (17) 0.0252 0.0373 BioCarta//Mn_IL-2 Receptor Beta Chain in T cell Activation      1/37 (42) 0.0579 0.0373 BioCarta//Mn_Influence of Ras and Rho proteins on G1 to S Transition      1/26 (33) 0.0409 0.0373 BioCarta//Mn_Integrin Signaling Pathway      1/37 (45) 0.0579 0.0373 BioCarta//Mn_Links between Pyk2 and Map Kinases      1/27 (42) 0.0424 0.0373 BioCarta//Mn_Multiple antiapoptotic pathways from IGF-1R signaling lead to BAD phosphorylation      1/15 (29) 0.0237 0.0373 BioCarta//Mn_Regulation of Splicing through Sam68      1/7 (8) 0.0111 0.0373 BioCarta//Mn_Role of MAL in Rho-Mediated Activation of SRF      1/19 (26) 0.0299 0.0373 BioCarta//Mn_Role of ?arrestins in the activation and targeting of MAP kinases      1/17 (40) 0.0268 0.0373 BioCarta//Mn_Roles of ?arrestin-dependent Recruitment of Src Kinases in GPCR Signaling      1/21 (34) 0.0331 0.0373 BioCarta//Mn_Signaling of Hepatocyte Growth Factor Receptor      1/35 (41) 0.0548 0.0373 BioCarta//Mn_Sprouty regulation of tyrosine kinase signals      1/18 (31) 0.0284 0.0373 BioCarta//Mn_Stat3 Signaling Pathway      1/8 (11) 0.0127 0.0373 BioCarta//Mn_Transcription factor CREB and its extracellular signals      1/22 (22) 0.0346 0.0373 BioCarta//Mn_Trefoil Factors Initiate Mucosal Healing      1/25 (88) 0.0393 0.0373 BioCarta//Mn_Angiotensin-converting enzyme 2 regulates heart function      1/13 (34) 0.0205 0.0373 BioCarta//Mn_Erk1/Erk2 Mapk Signaling pathway      1/29 (34) 0.0455 0.0374 BioCarta//Mn_Growth Hormone Signaling Pathway      1/27 (36) 0.0424 0.0374 BioCarta//Mn_Phospholipids as signalling intermediaries      1/25 (42) 0.0393 0.0390 BioCarta//Mn_CCR3 signaling in Eosinophils      1/22 (29) 0.0346 0.0393 BioCarta//Mn_Ceramide Signaling Pathway      1/22 (22) 0.0346 0.0393 BioCarta//Mn_Erk and PI-3 Kinase Are Necessary for Collagen Binding in Corneal Epithelia      1/22 (40) 0.0346 0.0393 BioCarta//Mn_Keratinocyte Differentiation      1/46 (67) 0.0717 0.0447 BioCarta//Mn_NFAT and Hypertrophy of the heart (Transcription in the broken heart)      1/47 (77) 0.0732 0.0447 BioCarta//Mn_Oxidative Stress Induced Gene Expression Via Nrf2      1/21 (26) 0.0331 0.0463 BioCarta//Mn_Regulation of eIF4e and p70 S6 Kinase      1/21 (25) 0.0331 0.0463 BioCarta//Mn_Role of ERBB2 in Signal Transduction and Oncology      1/21 (34) 0.0331 0.0463 BioCarta//Mn_PTEN dependent cell cycle arrest and apoptosis      1/18 (21) 0.0284 0.0563 BioCarta//Mn_Role of Erk5 in Neuronal Survival      1/17 (36) 0.0268 0.0639 BioCarta//Mn_MAPKinase Signaling Pathway      1/82 (85) 0.1260 0.0750 BioCarta//Mn_Cadmium induces DNA synthesis and proliferation in macrophages      1/15 (21) 0.0237 0.0806 BioCarta//Mn_Phosphorylation of MEK1 by cdk5/p35 down regulates the MAP kinase pathway      1/13 (17) 0.0205 0.0979 BioCarta//Mn_Pelp1 Modulation of Estrogen Receptor Activity      1/6 (10) 0.0095 0.2265

Cluster 13 has 20 gene products

ArrayXPath has identified 1 out of 20 input elements in 1 out of 277 BioCarta pathways.

Clusters BioCarta 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50

Pathway Identified node p-value q-value BioCarta//Mn_BTG family proteins and cell cycle regulation      1/11 (13) 0.0087 0.0087

Cluster 14 has 10 gene products

ArrayXPath has identified 2 out of 10 input elements in 1 out of 277 BioCarta pathways.

Clusters BioCarta 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50

Pathway Identified node p-value q-value BioCarta//Mn_Circadian Rhythms      1/6 (13) 0.0048 0.0048

Cluster 15 has 89 gene products

ArrayXPath has identified 13 out of 89 input elements in 58 out of 277 BioCarta pathways.

Clusters BioCarta 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50

Pathway Identified node p-value q-value BioCarta//Mn_D4-GDI Signaling Pathway      2/12 (15) 0.0036 0.0331 BioCarta//Mn_T Cytotoxic Cell Surface Molecules      2/14 (14) 0.0049 0.0331 BioCarta//Mn_T Helper Cell Surface Molecules      2/14 (14) 0.0049 0.0331 BioCarta//Mn_Fc Epsilon Receptor I Signaling in Mast Cells      3/37 (47) 0.0024 0.0331 BioCarta//Mn_Effects of calcineurin in Keratinocyte Differentiation      2/17 (32) 0.0072 0.0408 BioCarta//Mn_Caspase Cascade in Apoptosis      2/22 (27) 0.0120 0.0581 BioCarta//Mn_B Lymphocyte Cell Surface Molecules      2/9 (9) 0.0020 0.0670 BioCarta//Mn_IL 5 Signaling Pathway      1/8 (19) 0.0619 0.1307 BioCarta//Mn_Neutrophil and Its Surface Molecules      1/8 (12) 0.0619 0.1307 BioCarta//Mn_IL 18 Signaling Pathway      1/6 (8) 0.0468 0.1307 BioCarta//Mn_Activation of PKC through G protein coupled receptor      1/7 (8) 0.0544 0.1307 BioCarta//Mn_g-Secretase mediated ErbB4 Signaling Pathway      1/8 (20) 0.0619 0.1307 BioCarta//Mn_Phospholipase C d1 in phospholipid associated cell signaling      1/5 (10) 0.0391 0.1307 BioCarta//Mn_Phospholipase C Signaling Pathway      1/8 (12) 0.0619 0.1307 BioCarta//Mn_Adhesion Molecules on Lymphocyte      1/9 (10) 0.0694 0.1379 BioCarta//Mn_NFkB activation by Nontypeable Hemophilus influenzae      1/23 (42) 0.1688 0.1391 BioCarta//Mn_IL12 and Stat4 Dependent Signaling Pathway in Th1 Development      1/23 (29) 0.1688 0.1391 BioCarta//Mn_Activation of Src by Protein-tyrosine phosphatase alpha      1/11 (29) 0.0842 0.1391 BioCarta//Mn_Cadmium induces DNA synthesis and proliferation in macrophages      1/15 (21) 0.1133 0.1391 BioCarta//Mn_CBL mediated ligand-induced downregulation of EGF receptors      1/12 (46) 0.0916 0.1391 BioCarta//Mn_Nitric Oxide Signaling Pathway      1/19 (22) 0.1414 0.1391 BioCarta//Mn_Pertussis toxin-insensitive CCR5 Signaling in Macrophage      1/16 (35) 0.1204 0.1391 BioCarta//Mn_Role of MEF2D in T-cell Apoptosis      1/18 (45) 0.1345 0.1391 BioCarta//Mn_Thrombin signaling and protease-activated receptors      1/21 (30) 0.1552 0.1391 BioCarta//Mn_TPO Signaling Pathway      1/23 (54) 0.1688 0.1391 BioCarta//Mn_Transcription factor CREB and its extracellular signals      1/22 (22) 0.1620 0.1391 BioCarta//Mn_Trka Receptor Signaling Pathway      1/13 (13) 0.0989 0.1391 BioCarta//Mn_Eicosanoid Metabolism      1/20 (20) 0.1484 0.1391 BioCarta//Mn_FAS signaling pathway ( CD95 )      1/28 (32) 0.2019 0.1392 BioCarta//Mn_TNFR1 Signaling Pathway      1/28 (35) 0.2019 0.1392 BioCarta//Mn_CXCR4 Signaling Pathway      1/24 (35) 0.1755 0.1392 BioCarta//Mn_PDGF Signaling Pathway      1/27 (61) 0.1954 0.1392 BioCarta//Mn_Phospholipids as signalling intermediaries      1/25 (42) 0.1822 0.1392 BioCarta//Mn_EGF Signaling Pathway      1/27 (54) 0.1954 0.1404 BioCarta//Mn_Growth Hormone Signaling Pathway      1/27 (36) 0.1954 0.1404 BioCarta//Mn_Links between Pyk2 and Map Kinases      1/27 (42) 0.1954 0.1404 BioCarta//Mn_Attenuation of GPCR Signaling      1/12 (12) 0.0916 0.1406 BioCarta//Mn_Selective expression of chemokine receptors during T-cell polarization      1/29 (55) 0.2084 0.1408 BioCarta//Mn_Monocyte and its Surface Molecules      1/11 (12) 0.0842 0.1423 BioCarta//Mn_Lck and Fyn tyrosine kinases in initiation of TCR Activation      1/11 (18) 0.0842 0.1423 BioCarta//Mn_Signal transduction through IL1R      1/30 (41) 0.2148 0.1423 BioCarta//Mn_BCR Signaling Pathway      1/33 (52) 0.2338 0.1436 BioCarta//Mn_Bioactive Peptide Induced Signaling Pathway      1/33 (50) 0.2338 0.1436 BioCarta//Mn_Signaling Pathway from G-Protein Families      1/32 (39) 0.2275 0.1436 BioCarta//Mn_Msp/Ron Receptor Signaling Pathway      1/6 (27) 0.0468 0.1436 BioCarta//Mn_Apoptotic Signaling in Response to DNA Damage      1/22 (30) 0.1620 0.1440 BioCarta//Mn_CCR3 signaling in Eosinophils      1/22 (29) 0.1620 0.1440 BioCarta//Mn_Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling      1/32 (42) 0.2275 0.1450 BioCarta//Mn_Ion Channel and Phorbal Esters Signaling Pathway      1/5 (7) 0.0391 0.1468 BioCarta//Mn_Activation of Csk by cAMP-dependent Protein Kinase Inhibits Signaling through the T Cell Receptor      1/21 (25) 0.1552 0.1498 BioCarta//Mn_Oxidative Stress Induced Gene Expression Via Nrf2      1/21 (26) 0.1552 0.1498 BioCarta//Mn_Regulation of eIF4e and p70 S6 Kinase      1/21 (25) 0.1552 0.1498 BioCarta//Mn_CTL mediated immune response against target cells      1/15 (28) 0.1133 0.1530 BioCarta//Mn_Th1/Th2 Differentiation      1/18 (90) 0.1345 0.1566 BioCarta//Mn_Role of EGF Receptor Transactivation by GPCRs in Cardiac Hypertrophy      1/18 (31) 0.1345 0.1566 BioCarta//Mn_T Cell Receptor Signaling Pathway      1/43 (55) 0.2943 0.1775 BioCarta//Mn_Keratinocyte Differentiation      1/46 (67) 0.3115 0.1846 BioCarta//Mn_HIV-I Nef: negative effector of Fas and TNF      1/56 (76) 0.3664 0.2134

Cluster 16 has 9 gene products

ArrayXPath has identified 3 out of 9 input elements in 5 out of 277 BioCarta pathways.

Clusters BioCarta 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50

Pathway Identified node p-value q-value BioCarta//Mn_g-Secretase mediated ErbB4 Signaling Pathway      1/8 (20) 0.0189 0.0237 BioCarta//Mn_SREBP control of lipid synthesis      1/6 (27) 0.0142 0.0237 BioCarta//Mn_Proteolysis and Signaling Pathway of Notch      1/6 (20) 0.0142 0.0237 BioCarta//Mn_Internal Ribosome entry pathway      1/6 (25) 0.0142 0.0237 BioCarta//Mn_Presenilin action in Notch and Wnt signaling      1/14 (31) 0.0330 0.0330

Cluster 17 has 5 gene products but doesn't match to BioCarta pathways

Cluster 18 has 11 gene products but doesn't match to BioCarta pathways

Cluster 19 has 40 gene products

ArrayXPath has identified 3 out of 40 input elements in 6 out of 277 BioCarta pathways.

Clusters BioCarta 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50

Pathway Identified node p-value q-value BioCarta//Mn_Stathmin and breast cancer resistance to antimicrotubule agents      1/20 (23) 0.0469 0.0295 BioCarta//Mn_Nerve growth factor pathway (NGF)      1/19 (41) 0.0446 0.0295 BioCarta//Mn_Trka Receptor Signaling Pathway      1/13 (13) 0.0307 0.0295 BioCarta//Mn_Angiotensin-converting enzyme 2 regulates heart function      1/13 (34) 0.0307 0.0321 BioCarta//Mn_Phosphorylation of MEK1 by cdk5/p35 down regulates the MAP kinase pathway      1/13 (17) 0.0307 0.0321 BioCarta//Mn_Erk1/Erk2 Mapk Signaling pathway      1/29 (34) 0.0675 0.0353

Cluster 20 has 17 gene products

ArrayXPath has identified 2 out of 17 input elements in 55 out of 277 BioCarta pathways.

Clusters BioCarta 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50

Pathway Identified node p-value q-value BioCarta//Mn_Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling      2/32 (42) 0.0006 0.0025 BioCarta//Mn_Bioactive Peptide Induced Signaling Pathway      2/33 (50) 0.0007 0.0025 BioCarta//Mn_Erk1/Erk2 Mapk Signaling pathway      2/29 (34) 0.0005 0.0025 BioCarta//Mn_fMLP induced chemokine gene expression in HMC-1 cells      2/34 (55) 0.0007 0.0025 BioCarta//Mn_Links between Pyk2 and Map Kinases      2/27 (42) 0.0004 0.0025 BioCarta//Mn_Role of MAL in Rho-Mediated Activation of SRF      2/19 (26) 0.0002 0.0025 BioCarta//Mn_Roles of ?arrestin-dependent Recruitment of Src Kinases in GPCR Signaling      2/21 (34) 0.0003 0.0025 BioCarta//Mn_Signaling of Hepatocyte Growth Factor Receptor      2/35 (41) 0.0008 0.0025 BioCarta//Mn_Integrin Signaling Pathway      2/37 (45) 0.0008 0.0025 BioCarta//Mn_Phosphorylation of MEK1 by cdk5/p35 down regulates the MAP kinase pathway      2/13 (17) 0.0001 0.0029 BioCarta//Mn_MAPKinase Signaling Pathway      2/82 (85) 0.0042 0.0114 BioCarta//Mn_Human Cytomegalovirus and Map Kinase Pathways      1/16 (17) 0.0252 0.0265 BioCarta//Mn_Calcium Signaling by HBx of Hepatitis B virus      1/8 (8) 0.0127 0.0265 BioCarta//Mn_CCR3 signaling in Eosinophils      1/22 (29) 0.0346 0.0265 BioCarta//Mn_Erk and PI-3 Kinase Are Necessary for Collagen Binding in Corneal Epithelia      1/22 (40) 0.0346 0.0265 BioCarta//Mn_IGF-1 Signaling Pathway      1/20 (45) 0.0315 0.0265 BioCarta//Mn_IL 2 signaling pathway      1/22 (47) 0.0346 0.0265 BioCarta//Mn_Inhibition of Cellular Proliferation by Gleevec      1/22 (23) 0.0346 0.0265 BioCarta//Mn_Inhibition of Matrix Metalloproteinases      1/9 (15) 0.0142 0.0265 BioCarta//Mn_Multiple antiapoptotic pathways from IGF-1R signaling lead to BAD phosphorylation      1/15 (29) 0.0237 0.0265 BioCarta//Mn_Nerve growth factor pathway (NGF)      1/19 (41) 0.0299 0.0265 BioCarta//Mn_Ras Signaling Pathway      1/22 (23) 0.0346 0.0265 BioCarta//Mn_Regulation of Splicing through Sam68      1/7 (8) 0.0111 0.0265 BioCarta//Mn_Role of ERBB2 in Signal Transduction and Oncology      1/21 (34) 0.0331 0.0265 BioCarta//Mn_Role of Erk5 in Neuronal Survival      1/17 (36) 0.0268 0.0265 BioCarta//Mn_Sprouty regulation of tyrosine kinase signals      1/18 (31) 0.0284 0.0265 BioCarta//Mn_The IGF-1 Receptor and Longevity      1/14 (14) 0.0221 0.0265 BioCarta//Mn_Transcription factor CREB and its extracellular signals      1/22 (22) 0.0346 0.0265 BioCarta//Mn_Trka Receptor Signaling Pathway      1/13 (13) 0.0205 0.0265 BioCarta//Mn_TPO Signaling Pathway      1/23 (54) 0.0362 0.0270 BioCarta//Mn_CXCR4 Signaling Pathway      1/24 (35) 0.0377 0.0275 BioCarta//Mn_EGF Signaling Pathway      1/27 (54) 0.0424 0.0276 BioCarta//Mn_Growth Hormone Signaling Pathway      1/27 (36) 0.0424 0.0276 BioCarta//Mn_Influence of Ras and Rho proteins on G1 to S Transition      1/26 (33) 0.0409 0.0276 BioCarta//Mn_PDGF Signaling Pathway      1/27 (61) 0.0424 0.0276 BioCarta//Mn_Trefoil Factors Initiate Mucosal Healing      1/25 (88) 0.0393 0.0276 BioCarta//Mn_How Progesterone Initiates the Oocyte Maturation      1/29 (31) 0.0455 0.0290 BioCarta//Mn_IL 6 signaling pathway      1/21 (48) 0.0331 0.0300 BioCarta//Mn_Insulin Signaling Pathway      1/21 (48) 0.0331 0.0300 BioCarta//Mn_mCalpain and friends in Cell motility      1/21 (37) 0.0331 0.0300 BioCarta//Mn_Signaling Pathway from G-Protein Families      1/32 (39) 0.0502 0.0312 BioCarta//Mn_BCR Signaling Pathway      1/33 (52) 0.0517 0.0316 BioCarta//Mn_EPO Signaling Pathway      1/19 (36) 0.0299 0.0320 BioCarta//Mn_METS affect on Macrophage Differentiation      1/18 (32) 0.0284 0.0326 BioCarta//Mn_Role of EGF Receptor Transactivation by GPCRs in Cardiac Hypertrophy      1/18 (31) 0.0284 0.0326 BioCarta//Mn_Fc Epsilon Receptor I Signaling in Mast Cells      1/37 (47) 0.0579 0.0333 BioCarta//Mn_IL-2 Receptor Beta Chain in T cell Activation      1/37 (42) 0.0579 0.0333 BioCarta//Mn_p38 MAPK Signaling Pathway      1/37 (39) 0.0579 0.0333 BioCarta//Mn_Role of ?arrestins in the activation and targeting of MAP kinases      1/17 (40) 0.0268 0.0349 BioCarta//Mn_Regulation of transcriptional activity by PML      1/17 (25) 0.0268 0.0349 BioCarta//Mn_Cadmium induces DNA synthesis and proliferation in macrophages      1/15 (21) 0.0237 0.0373 BioCarta//Mn_IL 3 signaling pathway      1/15 (30) 0.0237 0.0373 BioCarta//Mn_T Cell Receptor Signaling Pathway      1/43 (55) 0.0671 0.0379 BioCarta//Mn_Keratinocyte Differentiation      1/46 (67) 0.0717 0.0397 BioCarta//Mn_NFAT and Hypertrophy of the heart (Transcription in the broken heart)      1/47 (77) 0.0732 0.0398

Cluster 21 has 16 gene products

ArrayXPath has identified 1 out of 16 input elements in 1 out of 277 BioCarta pathways.

Clusters BioCarta 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50

Pathway Identified node p-value q-value BioCarta//Mn_Vitamin C in the Brain      1/11 (22) 0.0087 0.0087

Cluster 22 has 22 gene products

ArrayXPath has identified 2 out of 22 input elements in 5 out of 277 BioCarta pathways.

Clusters BioCarta 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50

Pathway Identified node p-value q-value BioCarta//Mn_IL 17 Signaling Pathway      1/15 (16) 0.0237 0.0331 BioCarta//Mn_Regulation of BAD phosphorylation      1/21 (30) 0.0331 0.0331 BioCarta//Mn_TGF beta signaling pathway      1/17 (73) 0.0268 0.0331 BioCarta//Mn_CDK Regulation of DNA Replication      1/15 (52) 0.0237 0.0395 BioCarta//Mn_Erythrocyte Differentiation Pathway      1/15 (21) 0.0237 0.0395

Cluster 23 has 66 gene products

ArrayXPath has identified 11 out of 66 input elements in 30 out of 277 BioCarta pathways.

Clusters BioCarta 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50

Pathway Identified node p-value q-value BioCarta//Mn_ATM Signaling Pathway      2/19 (32) 0.0073 0.0600 BioCarta//Mn_Cell Cycle: G2/M Checkpoint      2/23 (25) 0.0106 0.0600 BioCarta//Mn_p53 Signaling Pathway      2/16 (27) 0.0052 0.0877 BioCarta//Mn_Inhibition of Matrix Metalloproteinases      1/9 (15) 0.0627 0.1151 BioCarta//Mn_Extrinsic Prothrombin Activation Pathway      1/13 (24) 0.0894 0.1151 BioCarta//Mn_Effects of calcineurin in Keratinocyte Differentiation      1/17 (32) 0.1154 0.1151 BioCarta//Mn_Msp/Ron Receptor Signaling Pathway      1/6 (27) 0.0422 0.1151 BioCarta//Mn_Regulation of transcriptional activity by PML      1/17 (25) 0.1154 0.1151 BioCarta//Mn_Classical Complement Pathway      1/11 (60) 0.0761 0.1151 BioCarta//Mn_Lectin Induced Complement Pathway      1/10 (52) 0.0694 0.1151 BioCarta//Mn_Role of PI3K subunit p85 in regulation of Actin Organization and Cell Migration      1/14 (14) 0.0960 0.1151 BioCarta//Mn_Y branching of actin filaments      1/16 (42) 0.1090 0.1151 BioCarta//Mn_Cyclins and Cell Cycle Regulation      1/23 (46) 0.1532 0.1191 BioCarta//Mn_Influence of Ras and Rho proteins on G1 to S Transition      1/26 (33) 0.1716 0.1191 BioCarta//Mn_NF-kB Signaling Pathway      1/22 (48) 0.1470 0.1191 BioCarta//Mn_TNF/Stress Related Signaling      1/25 (31) 0.1655 0.1191 BioCarta//Mn_TNFR1 Signaling Pathway      1/28 (35) 0.1836 0.1191 BioCarta//Mn_How Progesterone Initiates the Oocyte Maturation      1/29 (31) 0.1896 0.1191 BioCarta//Mn_Rho cell motility signaling pathway      1/27 (29) 0.1776 0.1191 BioCarta//Mn_Cell Cycle: G1/S Check Point      1/28 (34) 0.1836 0.1198 BioCarta//Mn_Pertussis toxin-insensitive CCR5 Signaling in Macrophage      1/16 (35) 0.1090 0.1232 BioCarta//Mn_Acetylation and Deacetylation of RelA in The Nucleus      1/16 (34) 0.1090 0.1232 BioCarta//Mn_Complement Pathway      1/16 (30) 0.1090 0.1232 BioCarta//Mn_NFkB activation by Nontypeable Hemophilus influenzae      1/23 (42) 0.1532 0.1237 BioCarta//Mn_Toll-Like Receptor Pathway      1/32 (44) 0.2073 0.1255 BioCarta//Mn_Ceramide Signaling Pathway      1/22 (22) 0.1470 0.1312 BioCarta//Mn_Erythropoietin mediated neuroprotection through NF-kB      1/11 (17) 0.0761 0.1434 BioCarta//Mn_Keratinocyte Differentiation      1/46 (67) 0.2852 0.1668 BioCarta//Mn_SODD/TNFR1 Signaling Pathway      1/10 (18) 0.0694 0.1682 BioCarta//Mn_HIV-I Nef: negative effector of Fas and TNF      1/56 (76) 0.3367 0.1903

Cluster 24 has 16 gene products but doesn't match to BioCarta pathways

Cluster 25 has 14 gene products

ArrayXPath has identified 4 out of 14 input elements in 7 out of 277 BioCarta pathways.

Clusters BioCarta 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50

Pathway Identified node p-value q-value BioCarta//Mn_Mitochondrial Carnitine Palmitoyltransferase (CPT) System      1/3 (3) 0.0095 0.0396 BioCarta//Mn_Endocytotic role of NDK, Phosphins and Dynamin      1/13 (34) 0.0407 0.0424 BioCarta//Mn_Granzyme A mediated Apoptosis Pathway      1/11 (28) 0.0345 0.0424 BioCarta//Mn_Shuttle for transfer of acetyl groups from mitochondria to the cytosol      1/8 (11) 0.0252 0.0424 BioCarta//Mn_Control of skeletal myogenesis by HDAC & calcium/calmodulin-dependent kinase (CaMK)      1/27 (39) 0.0831 0.0495 BioCarta//Mn_Growth Hormone Signaling Pathway      1/27 (36) 0.0831 0.0495 BioCarta//Mn_Insulin Signaling Pathway      1/21 (48) 0.0651 0.0495

Cluster 26 has 21 gene products but doesn't match to BioCarta pathways

Cluster 27 has 26 gene products

ArrayXPath has identified 2 out of 26 input elements in 3 out of 277 BioCarta pathways.

Clusters BioCarta 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50

Pathway Identified node p-value q-value BioCarta//Mn_Downregulated of MTA-3 in ER-negative Breast Tumors      1/21 (29) 0.0331 0.0227 BioCarta//Mn_METS affect on Macrophage Differentiation      1/18 (32) 0.0284 0.0227 BioCarta//Mn_CBL mediated ligand-induced downregulation of EGF receptors      1/12 (46) 0.0190 0.0390

Cluster 28 has 46 gene products

ArrayXPath has identified 9 out of 46 input elements in 27 out of 277 BioCarta pathways.

Clusters BioCarta 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50

Pathway Identified node p-value q-value BioCarta//Mn_Pertussis toxin-insensitive CCR5 Signaling in Macrophage      1/16 (35) 0.0974 0.1052 BioCarta//Mn_BTG family proteins and cell cycle regulation      1/11 (13) 0.0679 0.1052 BioCarta//Mn_Nerve growth factor pathway (NGF)      1/19 (41) 0.1148 0.1052 BioCarta//Mn_Trka Receptor Signaling Pathway      1/13 (13) 0.0798 0.1052 BioCarta//Mn_Inactivation of Gsk3 by AKT causes accumulation of b-catenin in Alveolar Macrophages      1/26 (43) 0.1540 0.1052 BioCarta//Mn_Cadmium induces DNA synthesis and proliferation in macrophages      1/15 (21) 0.0916 0.1052 BioCarta//Mn_CTCF: First Multivalent Nuclear Factor      1/23 (26) 0.1374 0.1052 BioCarta//Mn_Neuropeptides VIP and PACAP inhibit the apoptosis of activated T cells      1/24 (40) 0.1430 0.1052 BioCarta//Mn_Overview of telomerase protein component gene hTert Transcriptional Regulation      1/8 (20) 0.0498 0.1052 BioCarta//Mn_Tumor Suppressor Arf Inhibits Ribosomal Biogenesis      1/12 (17) 0.0739 0.1052 BioCarta//Mn_WNT Signaling Pathway      1/26 (43) 0.1540 0.1052 BioCarta//Mn_TGF beta signaling pathway      1/17 (73) 0.1032 0.1052 BioCarta//Mn_Caspase Cascade in Apoptosis      1/22 (27) 0.1318 0.1052 BioCarta//Mn_IFN gamma signaling pathway      1/6 (28) 0.0376 0.1052 BioCarta//Mn_Th1/Th2 Differentiation      1/18 (90) 0.1090 0.1052 BioCarta//Mn_Role of EGF Receptor Transactivation by GPCRs in Cardiac Hypertrophy      1/18 (31) 0.1090 0.1071 BioCarta//Mn_Role of Mitochondria in Apoptotic Signaling      1/18 (37) 0.1090 0.1071 BioCarta//Mn_Inhibition of Cellular Proliferation by Gleevec      1/22 (23) 0.1318 0.1090 BioCarta//Mn_Selective expression of chemokine receptors during T-cell polarization      1/29 (55) 0.1704 0.1116 BioCarta//Mn_Telomeres, Telomerase, Cellular Aging, and Immortality      1/17 (30) 0.1032 0.1248 BioCarta//Mn_IL-2 Receptor Beta Chain in T cell Activation      1/37 (42) 0.2127 0.1285 BioCarta//Mn_p38 MAPK Signaling Pathway      1/37 (39) 0.2127 0.1285 BioCarta//Mn_GATA3 participate in activating the Th2 cytokine genes expression      1/15 (24) 0.0916 0.1439 BioCarta//Mn_Phosphorylation of MEK1 by cdk5/p35 down regulates the MAP kinase pathway      1/13 (17) 0.0798 0.1568 BioCarta//Mn_Msp/Ron Receptor Signaling Pathway      1/6 (27) 0.0376 0.1968 BioCarta//Mn_Erk1/Erk2 Mapk Signaling pathway      2/29 (34) 0.0131 0.2066 BioCarta//Mn_MAPKinase Signaling Pathway      1/82 (85) 0.4172 0.2428

Cluster 29 has 30 gene products

ArrayXPath has identified 1 out of 30 input elements in 1 out of 277 BioCarta pathways.

Clusters BioCarta 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50

Pathway Identified node p-value q-value BioCarta//Mn_Calcium Signaling by HBx of Hepatitis B virus      1/8 (8) 0.0063 0.0063

Cluster 30 has 19 gene products

ArrayXPath has identified 3 out of 19 input elements in 3 out of 277 BioCarta pathways.

Clusters BioCarta 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50

Pathway Identified node p-value q-value BioCarta//Mn_Proepithelin Conversion to Epithelin and Wound Repair Control      1/5 (39) 0.0119 0.0246 BioCarta//Mn_Sonic Hedgehog (Shh) Pathway      1/15 (26) 0.0353 0.0366 BioCarta//Mn_HIV-I Nef: negative effector of Fas and TNF      1/56 (76) 0.1276 0.0882

Cluster 31 has 7 gene products but doesn't match to BioCarta pathways

Cluster 32 has 77 gene products

ArrayXPath has identified 8 out of 77 input elements in 11 out of 277 BioCarta pathways.

Clusters BioCarta 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50

Pathway Identified node p-value q-value BioCarta//Mn_Role of PPAR-gamma Coactivators in Obesity and Thermogenesis      1/9 (12) 0.0559 0.0923 BioCarta//Mn_Visceral Fat Deposits and the Metabolic Syndrome      1/8 (11) 0.0498 0.0923 BioCarta//Mn_Extrinsic Prothrombin Activation Pathway      1/13 (24) 0.0798 0.0991 BioCarta//Mn_Intrinsic Prothrombin Activation Pathway      1/23 (36) 0.1374 0.0991 BioCarta//Mn_Sonic Hedgehog (Shh) Pathway      1/15 (26) 0.0916 0.0991 BioCarta//Mn_Cytokines and Inflammatory Response      1/26 (76) 0.1540 0.0991 BioCarta//Mn_Oxidative Stress Induced Gene Expression Via Nrf2      1/21 (26) 0.1261 0.0991 BioCarta//Mn_Cell Cycle: G1/S Check Point      1/28 (34) 0.1650 0.0991 BioCarta//Mn_Cytokine Network      1/21 (97) 0.1261 0.1041 BioCarta//Mn_Shuttle for transfer of acetyl groups from mitochondria to the cytosol      1/8 (11) 0.0498 0.1097 BioCarta//Mn_Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine      1/5 (5) 0.0314 0.2074

Cluster 33 has 17 gene products

ArrayXPath has identified 2 out of 17 input elements in 11 out of 277 BioCarta pathways.

Clusters BioCarta 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50

Pathway Identified node p-value q-value BioCarta//Mn_FXR and LXR Regulation of Cholesterol Metabolism      1/8 (14) 0.0127 0.0193 BioCarta//Mn_CBL mediated ligand-induced downregulation of EGF receptors      1/12 (46) 0.0190 0.0193 BioCarta//Mn_Map Kinase Inactivation of SMRT Corepressor      1/11 (14) 0.0174 0.0193 BioCarta//Mn_The role of FYVE-finger proteins in vesicle transport      1/6 (34) 0.0095 0.0193 BioCarta//Mn_SREBP control of lipid synthesis      1/6 (27) 0.0095 0.0194 BioCarta//Mn_Role of EGF Receptor Transactivation by GPCRs in Cardiac Hypertrophy      1/18 (31) 0.0284 0.0217 BioCarta//Mn_Sprouty regulation of tyrosine kinase signals      1/18 (31) 0.0284 0.0217 BioCarta//Mn_mCalpain and friends in Cell motility      1/21 (37) 0.0331 0.0225 BioCarta//Mn_EGF Signaling Pathway      1/27 (54) 0.0424 0.0259 BioCarta//Mn_Neuroregulin receptor degredation protein-1 Controls ErbB3 receptor recycling      1/4 (16) 0.0063 0.0388 BioCarta//Mn_Keratinocyte Differentiation      1/46 (67) 0.0717 0.0399

Cluster 34 has 11 gene products

ArrayXPath has identified 2 out of 11 input elements in 5 out of 277 BioCarta pathways.

Clusters BioCarta 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50

Pathway Identified node p-value q-value BioCarta//Mn_Role of ?arrestins in the activation and targeting of MAP kinases      1/17 (40) 0.0268 0.0204 BioCarta//Mn_Roles of ?arrestin-dependent Recruitment of Src Kinases in GPCR Signaling      1/21 (34) 0.0331 0.0204 BioCarta//Mn_Cytokine Network      1/21 (97) 0.0331 0.0204 BioCarta//Mn_IL 17 Signaling Pathway      1/15 (16) 0.0237 0.0204 BioCarta//Mn_beta-arrestins in GPCR Desensitization      1/14 (33) 0.0221 0.0681

Cluster 35 has 9 gene products

ArrayXPath has identified 3 out of 9 input elements in 19 out of 277 BioCarta pathways.

Clusters BioCarta 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50

Pathway Identified node p-value q-value BioCarta//Mn_Cell Cycle: G2/M Checkpoint      1/23 (25) 0.0538 0.0491 BioCarta//Mn_How Progesterone Initiates the Oocyte Maturation      1/29 (31) 0.0675 0.0491 BioCarta//Mn_RB Tumor Suppressor/Checkpoint Signaling in response to DNA damage      1/13 (17) 0.0307 0.0491 BioCarta//Mn_Sonic Hedgehog (SHH) Receptor Ptc1 Regulates cell cycle      1/11 (30) 0.0260 0.0491 BioCarta//Mn_Ceramide Signaling Pathway      1/22 (22) 0.0515 0.0491 BioCarta//Mn_Induction of apoptosis through DR3 and DR4/5 Death Receptors      1/30 (35) 0.0698 0.0491 BioCarta//Mn_SODD/TNFR1 Signaling Pathway      1/10 (18) 0.0236 0.0491 BioCarta//Mn_TACI and BCMA stimulation of B cell immune responses.      1/15 (22) 0.0353 0.0491 BioCarta//Mn_TNF/Stress Related Signaling      1/25 (31) 0.0584 0.0491 BioCarta//Mn_TNFR1 Signaling Pathway      1/28 (35) 0.0652 0.0491 BioCarta//Mn_TNFR2 Signaling Pathway      1/18 (32) 0.0423 0.0491 BioCarta//Mn_The 4-1BB-dependent immune response      1/18 (22) 0.0423 0.0495 BioCarta//Mn_Cystic fibrosis transmembrane conductance regulator and beta 2 adrenergic receptor pathway      1/11 (34) 0.0260 0.0548 BioCarta//Mn_Activation of Src by Protein-tyrosine phosphatase alpha      1/11 (29) 0.0260 0.0548 BioCarta//Mn_p38 MAPK Signaling Pathway      1/37 (39) 0.0856 0.0564 BioCarta//Mn_Keratinocyte Differentiation      1/46 (67) 0.1057 0.0655 BioCarta//Mn_HIV-I Nef: negative effector of Fas and TNF      1/56 (76) 0.1276 0.0747 BioCarta//Mn_MAPKinase Signaling Pathway      1/82 (85) 0.1829 0.1015 BioCarta//Mn_cdc25 and chk1 Regulatory Pathway in response to DNA damage      1/9 (13) 0.0213 0.2245

Cluster 36 has 12 gene products

ArrayXPath has identified 1 out of 12 input elements in 2 out of 277 BioCarta pathways.

Clusters BioCarta 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50

Pathway Identified node p-value q-value BioCarta//Mn_The IGF-1 Receptor and Longevity      1/14 (14) 0.0111 0.0056 BioCarta//Mn_Erythropoietin mediated neuroprotection through NF-kB      1/11 (17) 0.0087 0.0088

Cluster 37 has 4 gene products

ArrayXPath has identified 1 out of 4 input elements in 1 out of 277 BioCarta pathways.

Clusters BioCarta 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50

Pathway Identified node p-value q-value BioCarta//Mn_Reversal of Insulin Resistance by Leptin      1/3 (3) 0.0024 0.0024

Cluster 38 has 4 gene products

ArrayXPath has identified 1 out of 4 input elements in 2 out of 277 BioCarta pathways.

Clusters BioCarta 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50

Pathway Identified node p-value q-value BioCarta//Mn_Platelet Amyloid Precursor Protein Pathway      1/14 (15) 0.0111 0.0056 BioCarta//Mn_Fibrinolysis Pathway      1/11 (14) 0.0087 0.0088

Cluster 39 has 18 gene products

ArrayXPath has identified 3 out of 18 input elements in 8 out of 277 BioCarta pathways.

Clusters BioCarta 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50

Pathway Identified node p-value q-value BioCarta//Mn_CTCF: First Multivalent Nuclear Factor      1/23 (26) 0.0538 0.0324 BioCarta//Mn_NFkB activation by Nontypeable Hemophilus influenzae      1/23 (42) 0.0538 0.0324 BioCarta//Mn_Role of Tob in T-cell activation      1/21 (32) 0.0492 0.0324 BioCarta//Mn_TGF beta signaling pathway      1/17 (73) 0.0400 0.0324 BioCarta//Mn_CCR3 signaling in Eosinophils      1/22 (29) 0.0515 0.0324 BioCarta//Mn_IL 5 Signaling Pathway      1/8 (19) 0.0189 0.0324 BioCarta//Mn_FAS signaling pathway ( CD95 )      1/28 (32) 0.0652 0.0344 BioCarta//Mn_The Role of Eosinophils in the Chemokine Network of Allergy      1/6 (16) 0.0142 0.0600

Cluster 40 has 42 gene products

ArrayXPath has identified 6 out of 42 input elements in 8 out of 277 BioCarta pathways.

Clusters BioCarta 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50

Pathway Identified node p-value q-value BioCarta//Mn_IL 6 signaling pathway      1/21 (48) 0.0961 0.0877 BioCarta//Mn_CTCF: First Multivalent Nuclear Factor      1/23 (26) 0.1048 0.0877 BioCarta//Mn_WNT Signaling Pathway      1/26 (43) 0.1178 0.0877 BioCarta//Mn_CBL mediated ligand-induced downregulation of EGF receptors      1/12 (46) 0.0559 0.0877 BioCarta//Mn_Role of MAL in Rho-Mediated Activation of SRF      1/19 (26) 0.0873 0.0877 BioCarta//Mn_BCR Signaling Pathway      1/33 (52) 0.1475 0.0941 BioCarta//Mn_NFAT and Hypertrophy of the heart (Transcription in the broken heart)      1/47 (77) 0.2043 0.1141 BioCarta//Mn_Deregulation of CDK5 in Alzheimers Disease      1/10 (16) 0.0468 0.2090

Cluster 41 has 31 gene products

ArrayXPath has identified 2 out of 31 input elements in 6 out of 277 BioCarta pathways.

Clusters BioCarta 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50

Pathway Identified node p-value q-value BioCarta//Mn_Basic mechanism of action of PPARa, PPARb(d) and PPARg and effects on gene expression      1/4 (7) 0.0063 0.0195 BioCarta//Mn_Regulation of PGC-1a      1/17 (23) 0.0268 0.0207 BioCarta//Mn_beta-arrestins in GPCR Desensitization      1/14 (33) 0.0221 0.0207 BioCarta//Mn_IL-10 Anti-inflammatory Signaling Pathway      1/12 (16) 0.0190 0.0207 BioCarta//Mn_Nuclear Receptors in Lipid Metabolism and Toxicity      1/33 (40) 0.0517 0.0266 BioCarta//Mn_Toll-Like Receptor Pathway      1/32 (44) 0.0502 0.0266

Cluster 42 has 11 gene products but doesn't match to BioCarta pathways

Cluster 43 has 10 gene products but doesn't match to BioCarta pathways

Cluster 44 has 12 gene products

ArrayXPath has identified 3 out of 12 input elements in 6 out of 277 BioCarta pathways.

Clusters BioCarta 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50

Pathway Identified node p-value q-value BioCarta//Mn_Antisense Pathway      1/4 (13) 0.0095 0.0306 BioCarta//Mn_SODD/TNFR1 Signaling Pathway      1/10 (18) 0.0236 0.0381 BioCarta//Mn_Caspase Cascade in Apoptosis      1/22 (27) 0.0515 0.0554 BioCarta//Mn_Induction of apoptosis through DR3 and DR4/5 Death Receptors      1/30 (35) 0.0698 0.0563 BioCarta//Mn_HIV-I Nef: negative effector of Fas and TNF      1/56 (76) 0.1276 0.0823 BioCarta//Mn_MAPKinase Signaling Pathway      1/82 (85) 0.1829 0.0983

Cluster 45 has 17 gene products

ArrayXPath has identified 5 out of 17 input elements in 27 out of 277 BioCarta pathways.

Clusters BioCarta 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50

Pathway Identified node p-value q-value BioCarta//Mn_Rac 1 cell motility signaling pathway      2/22 (24) 0.0028 0.0212 BioCarta//Mn_Ras-Independent pathway in NK cell-mediated cytotoxicity      2/19 (19) 0.0021 0.0316 BioCarta//Mn_BCR Signaling Pathway      2/33 (52) 0.0063 0.0318 BioCarta//Mn_T Cell Receptor Signaling Pathway      2/43 (55) 0.0107 0.0401 BioCarta//Mn_Multi-Drug Resistance Factors      1/6 (14) 0.0236 0.0711 BioCarta//Mn_Phosphoinositides and their downstream targets.      1/18 (18) 0.0695 0.0735 BioCarta//Mn_Role of MAL in Rho-Mediated Activation of SRF      1/19 (26) 0.0733 0.0735 BioCarta//Mn_Role of PI3K subunit p85 in regulation of Actin Organization and Cell Migration      1/14 (14) 0.0544 0.0735 BioCarta//Mn_Tumor Suppressor Arf Inhibits Ribosomal Biogenesis      1/12 (17) 0.0468 0.0735 BioCarta//Mn_uCalpain and friends in Cell spread      1/17 (36) 0.0658 0.0735 BioCarta//Mn_Phospholipase C Signaling Pathway      1/8 (12) 0.0314 0.0735 BioCarta//Mn_Deregulation of CDK5 in Alzheimers Disease      1/10 (16) 0.0391 0.0735 BioCarta//Mn_Regulation of ck1/cdk5 by type 1 glutamate receptors      1/16 (37) 0.0620 0.0735 BioCarta//Mn_Regulators of Bone Mineralization      1/10 (55) 0.0391 0.0736 BioCarta//Mn_Links between Pyk2 and Map Kinases      1/27 (42) 0.1028 0.0737 BioCarta//Mn_Phospholipids as signalling intermediaries      1/25 (42) 0.0955 0.0737 BioCarta//Mn_Transcription factor CREB and its extracellular signals      1/22 (22) 0.0844 0.0737 BioCarta//Mn_WNT Signaling Pathway      1/26 (43) 0.0992 0.0737 BioCarta//Mn_Influence of Ras and Rho proteins on G1 to S Transition      1/26 (33) 0.0992 0.0746 BioCarta//Mn_Ras Signaling Pathway      1/22 (23) 0.0844 0.0747 BioCarta//Mn_Y branching of actin filaments      1/16 (42) 0.0620 0.0777 BioCarta//Mn_Agrin in Postsynaptic Differentiation      1/37 (47) 0.1387 0.0802 BioCarta//Mn_Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling      1/32 (42) 0.1209 0.0802 BioCarta//Mn_fMLP induced chemokine gene expression in HMC-1 cells      1/34 (55) 0.1280 0.0802 BioCarta//Mn_p38 MAPK Signaling Pathway      1/37 (39) 0.1387 0.0802 BioCarta//Mn_Fc Epsilon Receptor I Signaling in Mast Cells      1/37 (47) 0.1387 0.0802 BioCarta//Mn_MAPKinase Signaling Pathway      1/82 (85) 0.2861 0.1594

Cluster 46 has 57 gene products

ArrayXPath has identified 10 out of 57 input elements in 25 out of 277 BioCarta pathways.

Clusters BioCarta 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50

Pathway Identified node p-value q-value BioCarta//Mn_Gamma-aminobutyric Acid Receptor Life Cycle      1/12 (73) 0.0916 0.1528 BioCarta//Mn_Classical Complement Pathway      1/11 (60) 0.0842 0.1528 BioCarta//Mn_IL12 and Stat4 Dependent Signaling Pathway in Th1 Development      1/23 (29) 0.1688 0.1528 BioCarta//Mn_CTCF: First Multivalent Nuclear Factor      1/23 (26) 0.1688 0.1528 BioCarta//Mn_Erythrocyte Differentiation Pathway      1/15 (21) 0.1133 0.1528 BioCarta//Mn_Function of SLRP in Bone: An Integrated View      1/4 (4) 0.0314 0.1528 BioCarta//Mn_TGF beta signaling pathway      1/17 (73) 0.1274 0.1528 BioCarta//Mn_Eph Kinases and ephrins support platelet aggregation      1/10 (17) 0.0769 0.1528 BioCarta//Mn_Phosphoinositides and their downstream targets.      1/18 (18) 0.1345 0.1528 BioCarta//Mn_Regulation of BAD phosphorylation      1/21 (30) 0.1552 0.1528 BioCarta//Mn_IL-7 Signal Transduction      1/16 (29) 0.1204 0.1528 BioCarta//Mn_Cytokine Network      1/21 (97) 0.1552 0.1592 BioCarta//Mn_Role of Tob in T-cell activation      1/21 (32) 0.1552 0.1592 BioCarta//Mn_Cytokines and Inflammatory Response      1/26 (76) 0.1888 0.1614 BioCarta//Mn_Cell Cycle: G1/S Check Point      1/28 (34) 0.2019 0.1635 BioCarta//Mn_Signal transduction through IL1R      1/30 (41) 0.2148 0.1636 BioCarta//Mn_Toll-Like Receptor Pathway      1/32 (44) 0.2275 0.1636 BioCarta//Mn_BCR Signaling Pathway      1/33 (52) 0.2338 0.1636 BioCarta//Mn_p38 MAPK Signaling Pathway      1/37 (39) 0.2585 0.1658 BioCarta//Mn_Fc Epsilon Receptor I Signaling in Mast Cells      1/37 (47) 0.2585 0.1658 BioCarta//Mn_Th1/Th2 Differentiation      1/18 (90) 0.1345 0.1724 BioCarta//Mn_Complement Pathway      1/16 (30) 0.1204 0.2058 BioCarta//Mn_Steps in the Glycosylation of Mammalian N-linked Oligosaccarides      1/10 (10) 0.0769 0.2957 BioCarta//Mn_MAPKinase Signaling Pathway      1/82 (85) 0.4911 0.3023 BioCarta//Mn_Selective expression of chemokine receptors during T-cell polarization      2/29 (55) 0.0205 0.3160

Cluster 47 has 10 gene products

ArrayXPath has identified 2 out of 10 input elements in 11 out of 277 BioCarta pathways.

Clusters BioCarta 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50

Pathway Identified node p-value q-value BioCarta//Mn_Antigen Dependent B Cell Activation      1/10 (27) 0.0158 0.0276 BioCarta//Mn_CTL mediated immune response against target cells      1/15 (28) 0.0237 0.0276 BioCarta//Mn_HIV Induced T Cell Apoptosis      1/11 (27) 0.0174 0.0276 BioCarta//Mn_Regulation of transcriptional activity by PML      1/17 (25) 0.0268 0.0276 BioCarta//Mn_Stress Induction of HSP Regulation      1/14 (22) 0.0221 0.0276 BioCarta//Mn_Eicosanoid Metabolism      1/20 (20) 0.0315 0.0277 BioCarta//Mn_FAS signaling pathway ( CD95 )      1/28 (32) 0.0440 0.0339 BioCarta//Mn_IL-2 Receptor Beta Chain in T cell Activation      1/37 (42) 0.0579 0.0397 BioCarta//Mn_Keratinocyte Differentiation      1/46 (67) 0.0717 0.0442 BioCarta//Mn_HIV-I Nef: negative effector of Fas and TNF      1/56 (76) 0.0869 0.0487 BioCarta//Mn_Bystander B Cell Activation      1/6 (16) 0.0095 0.0586

Cluster 48 has 3 gene products but doesn't match to BioCarta pathways

Cluster 49 has 15 gene products but doesn't match to BioCarta pathways

Cluster 50 has 10 gene products

ArrayXPath has identified 1 out of 10 input elements in 1 out of 277 BioCarta pathways.

Clusters BioCarta 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50

Pathway Identified node p-value q-value BioCarta//Mn_Wnt/LRP6 Signalling      1/7 (27) 0.0056 0.0056

Last Updated (14, February, 2005)  powered by SNUBI