|
Table
1. List of genes showing cancer and/or drug specific effects and the
pattern distance, FDR (False Discovery Rate) and the number of cells
significantly changed for each gene expression profile.
|
|
Gene description
|
d
|
Noa
(=n)
|
Drug effect
|
Cell-line effect
|
|
1336:
Nuclear aconitase mRNA, encoding mitochondrial
|
3
|
(6)
|
CPT-11
|
|
|
2323:
Transcription factor ZFM1 isoform B3. SF1: splicing factor 1
|
3
|
(3)
|
|
SNU601
|
|
1409:
Alpha-2-macroglobulin.
|
4
|
(6)
|
|
SNU601
|
|
1559:
immunoglobulin kappa light chain
|
4
|
(7)
|
Doxorubicin
|
|
|
223:
Ferritin heavy chain.
|
4
|
(6)
|
|
SNU1
|
|
610:
Serine protease (Omi). PRSS25, protease, serine, 25
|
4
|
(6)
|
|
SNU620
|
|
22: cytochrome b5. NQO1: NAD(P)H dehydrogenase, quinone 1
|
5
|
(7)
|
|
AGS
|
|
1946:
DNA
polymerase epsilon, catalytic polype
|
5
|
(7)
|
|
SNU216
|
|
2054:
MAPK6: mitogen activated PK 6. (ERK3 protein kinase.)
|
5
|
(6)
|
Cisplatin
|
|
|
328:
Farnesyltransferase alpha-subunit.
|
5
|
(7)
|
|
M1
|
|
1863:RNA
for c-fes. FES: felin sarcoma oncogene
|
5
|
(7)
|
|
M1
|
|
2205:
X-box binding protein-1 (XBP-1).
|
5
|
(7)
|
|
AGS
|
|
389:
FABP5: Fatty acid binding protein homologue (psoriasis associated)
|
5
|
(7)
|
|
M74
|
|
1992:
GDNF
family receptor alpha 2 (GFRA2)
|
5
|
(7)
|
|
M74
|
|
1061:
zinc finger protein FPM315. (ZNF263)
|
5
|
(7)
|
|
SNU668
|
|
1281:
Putative src-like adapter protein (SLAP)
|
5
|
(7)
|
|
SNU620
|
|
1139:
Pyrroline 5-carboxylate reductase.
|
6
|
(12)
|
|
AGS,
SNU1
|
|
1855:
Rohu mRNA for rhodanese (HSROHU).
|
6
|
(9)
|
Cisplatin
|
|
|
883:
mRNA for APRIL protein. Acidic protein rich in leucines
|
6
|
(8)
|
|
AGS
|
|
877:
Glutathione peroxidase (GPX1).
|
6
|
(8)
|
|
AGS
|
|
212:
mRNA for P1cdc47. MCM7 minichromosome maintenance deficient 7
|
6
|
(8)
|
|
SNU601
|
|
1750:
(clone
PWHCLC2-8) cardiac myosin light chain 2
|
6
|
(8)
|
|
SNU668
|
|
821:
rhoGAP protein.
|
6
|
(8)
|
|
M74
|
|
359:
Human MHC class I HLA-C-alpha-2 chain and alternative mRNA
|
6
|
(7)
|
Doxorubicin
|
|
|
1948:
UBE3A:ubiquitin prot. Ligase E3A (HPV E6-asso prot., Angelman synd)
|
6
|
(7)
|
Taxol
|
|
|
995:
KIAA0406.
|
6
|
(7)
|
Taxol
|
|
|
382:
mRNA for Pr22 protein. STMN1: stethmin 1/onprotein 18
|
6
|
(8)
|
|
SNU601
|
|
2046:
LAMA2: laminin, alpha 2 (merosin, congenital muscular dystrophy) M
chain. |
7
|
(13)
|
|
SNU620,SNU1
|
|
848:
mRNA for KIAA0385 gene.
|
7
|
(9)
|
|
SNU620
|
|
990:
Human mRNA for HLA class I locus C heavy chain
|
7
|
(8)
|
Doxorubicin
|
|
|
203:
Ras-related protein (Krev-1). RAP1A: RAP1A, member of RAS oncogene
family
|
7
|
(8)
|
Cisplatin
|
|
|
1456:
mRNA for KIAA0288 gene.
|
7
|
(7)
|
|
M74,
SNU1
|
|
125:
Myo-inositol monophosphatase 2.
|
8
|
(11)
|
CPT-11
|
|
|
969:
SLC1A4: solute carrier family 1 (glutamate/neutral amino acid
transporter), member 4
|
8
|
(12)
|
Taxol,
|
M1
|
|
549:
SLC16A3: solute carrier family 16 (MCT3, Monocarboxylate
transporters), member 3
|
9
|
(14)
|
TSA,
|
SNU601,SNU620
|
|
1652:
G1P3: interferon, alpha-inducible protein (cDNA, IFI616)
|
10
|
(15)
|
Doxorubicin
|
|
|
145:
CDC2: cell division cycle 2, G1 to S and G2 to M
|
10
|
(13)
|
5-FU
|
|