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Disease name
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근육위축가쪽경화증
(Amyotrophic lateral sclerosis)
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Study name
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근위축성측삭경화증에서 운동신경세포 사멸에 관여하는 성상세포의 글루탐산 수송체(EAAT2) 유전자 조절기전 연구 |
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Government department
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보건복지부 |
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Enterprise
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보건의료연구개발 |
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Institute
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서울대학교 의과대학 |
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Department
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내분비생리학 |
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Duration
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2010-04-01~2012-03-31 |
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Director
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류훈 |
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Email
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hoonryu@snu.ac.kr |
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Contact
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02-740-8904 |
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References
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Differential expression of c-Ret in motor neurons versus non-neuronal cells is linked to the pathogenesis of ALS. Ryu H, Jeon GS, Cashman NR, Kowall NW, Lee J. Lab Invest. 2011 Jan 31. [Epub ahead of print]
PMID:
21283077
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The failure of mitochondria leads to neurodegeneration: Do mitochondria need a jump start? Lee J, Boo JH, Ryu H. Adv Drug Deliv Rev. 2009 Nov 30;61(14):1316-23. Epub 2009 Aug 27.
PMID:
19716395
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Differential regulation of neuronal and inducible nitric oxide synthase (NOS) in the spinal cord of mutant SOD1 (G93A) ALS mice. Lee J, Ryu H, Kowall NW. Biochem Biophys Res Commun. 2009 Sep 11;387(1):202-6. Epub 2009 J
PMID:
19580782
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Motor neuronal protection by L-arginine prolongs survival of mutant SOD1 (G93A) ALS mice. Lee J, Ryu H, Kowall NW. Biochem Biophys Res Commun. 2009 Jul 10;384(4):524-9. Epub 2009 May 8.
PMID:
19427829
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Activation of Ets-2 by oxidative stress induces Bcl-xL expression and accounts for glial survival in amyotrophic lateral sclerosis. Lee J, Kannagi M, Ferrante RJ, Kowall NW, Ryu H. FASEB J. 2009 Jun;23(6):1739-49. Epub 2009 Jan 29.
PMID:
19179380
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Increased stem cell proliferation in the spinal cord of adult amyotrophic lateral sclerosis transgenic mice. Guan YJ, Wang X, Wang HY, Kawagishi K, Ryu H, Huo CF, Shimony EM, Kristal BS, Kuhn HG, Friedlander RM. J Neurochem. 2007 Aug;102(4):1125-38. Epu
PMID:
17472707
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Translational therapeutic strategies in amyotrophic lateral sclerosis. Ryu H, Ferrante RJ. Mini Rev Med Chem. 2007 Feb;7(2):141-50. Review.
PMID:
17305588
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Sodium phenylbutyrate prolongs survival and regulates expression of anti-apoptotic genes in transgenic amyotrophic lateral sclerosis mice. Ryu H, Smith K, Camelo SI, Carreras I, Lee J, Iglesias AH, Dangond F, Cormier KA, Cudkowicz ME, Brown RH Jr, Ferran
PMID:
15934930
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