ࡱ> RRoot EntryЅL,{UFileHeaderXDocInfoJRBodyText ,{@; ,{S !"#$%&'()*+,-.0123456789TVWXYZ[\]^_`bcdefghijklmnopqrstuvwxRoot Entry&FileHeaderXDocInfoJMBodyText @   !"#$%&'()*+,-.0123456789;<=>?@ABCDEFGHIJKLMNOPQHwpSummaryInformation.CBinData  PrvImage PrvText !"#$%&'()*+,-./0123456789:;<=>?@ABDEFGHIKLMNOPQRSTUVWYZ[<T ȴ l| \ DNA microarray, Array CGH, Tissue MicroarrayX i pt0 x  Developing a data model for integrative analysis of DNA microarray, array CGH and tissue microarray for cancer genomics research Hye Won Lee, M.S., Yu Rang Park, B.S., Jung Hoon Woo, B.S., Ju Han Kim, M.D. Ph.D. Seoul National University Biomedical Informatics (SNUBI), Seoul National University College of Medicine, Seoul 110-799, Korea, correspondence to juhan@snu.ac.kr Abstract: Cancer genomics studies using DNA microarray have been increased the utility of gene expression profiles to classify tumors into clinically relevant subtypes and predict prognosis of patients. Tissue Microarray (TMA) and array Comparative Genomics Hybridization (arrayCGH) technologies are used for identifying molecular markers from population-based analysis and analyzing genomic structure, respectively. Integration of clinical information and various biological data such as DNA microarray, arrayCGH, and TMA data is helpful to understand underlying biolog>GIF89atɻxxxkkk]]]PPPCCC555((( d`LH00`Hذ̘`H0|pdXL@`0H `H0`dHL`H0xp`XH@0d LȰ``HH00dLؘȀ`H0xp`XH@d0L `H0d`LH`H0|pdXL@0`$H`dHL00`HذȘdL0xp`XH@0` HdH0ȳ``HHdL0xp`XH@`0H Ը̰ĠऀؘpȈXxHp@h@d8`8X0xT0pH dxddxd`d`p`|``x`p``x`!,t H*\ȰÇ#JHŋ3jȱǏ CIɓ(S\ɲ˗0cʜI͔s'Ϝ~ tP==ХMuz4ѡVj}gׯQwKaQhE)m֤kIXo=k5ݿN*X5$X_XoWRWF8ٰi=1ᤎ1ŐYymg̃9Hb:iz=NUږ[%L>_Mcө?N9}><ﲿnmpz淾 ~l|7gۀ1 R_GߑW`A&a`Rم[Xpm߇ 睇7\Z8aZg]0`֛}&\]Ҙ1ycf_)`K_zQ` h$Qai'M /b9禓(]AUJ'cl%w{ b&^d]2Yn.ZtIgAbZP({xi* frXm3rSn]9yVJii`Za=భGVj)2*ɥ%Q荾 b+ea[ڨjnծ+xz+b\k߫Z`C G,eFԮZ\nVڒM *+{gl&Kܰ*ĬUᬛ/:zחGA)lp8F:Xn%֠u JĂ,mV mŒz̴VWqtq2d,xPW v^L+wݎu)7M䔗_ߍ.B=Bj es㏣;2/4(b>y mNR}g1'+鎳'!g{H.tɮz5WR4.h5 f WśH՝c5إ3[X՟ڭXرMJ7>lJH.Ida.%F2Ͱ;Yek qB 00 a[vI gK&*QopXA%s;ƌfB̾7NBˑ$;E uu!?8z628@ rha%LU~h|\ո}~ʟ-IW;$0d8|'#- /KIB |0,\ry,楎A.Tդ7 Ɩj w/?̐ߨVQL!76]#W=s D,{@uKͅRP1* EN^(m3NF\#~mCI&xN۶pUT8Crŏ(]yW_K:>pwH|+g(;{d늀Ϲ>d(1[{q|>Jُw֯Qz읥2Sc&^M iC}a?A7an glKLDtXd_|#<01`9ݤ |[Pe9Ζr-q$[ [5-q)%QhS<=Ot?KsBeԤq3΍V]&%eER&&ŀӏKf* ($ =(5%XV0z~A9G[ =}M%a]{7w&nNjԝy]$~Ěyy$c@9=ަ(`x^n-=uzC=uzC:WU!kz~kު5=Uo{<k-MJM^?u4qyԥn ݴo`Z#83gb"Xz' K2;Kz&_Y/[߬-Af9axChm a-|$fn:ɸ7JHsh姷m\mwF [,j%, eȔz۞g #7[}-y,ezPyN?BFvMa1~n K]e$\`xE񞢡$Fg)gl 6{><U\okUyԴe3-v)x5snw:k u&λ~1>PKz5׍} {i*kxpm>l,ruflaw y"V5;68 ƾDk|k|k|nkz~k_SUo/K=[ogvޢc:To{kު5=Uoc\M`Zug7: jǗw {3~$'tT, QdlP'8[Bdn Ss~muݷvYR3? ѬB]70Vh?mxel'Ek`5zsGMķ~|VûϚ^t}uGK;~ߡ[Ef?/[[yoyތNz7mgKegMyp}sL[z=uzv~\UCWq4}N=P>{Bƨߝ zRA4ToωI5ջ'BzP=''TICTS{"' szRM4ToωI5ջ'BzP=''To9MEo$Dg. Cm[ƾߌu5t:WUm\as[¾ֹza_{X\V=uzC:߸qo=6G;Eؘ$M DŭDQIB < L#ƿvwXQMQWEly /964Xg4CbJv<3N̉aqϤ|k[IJھΛvwG|wuT;$n%*.?|K!:oZonXB"=]LN 2;{5fo,Bm X%[ƷJ|<9j; ߝg 7{l>#/>cy~}3\@}MkYV87 A!so:W+z&j;<αJCqyؘ$H%&O(Bȟ5LRؐY)#B?/ ?['qy8JjKD'Zq?GCHm!+Q7< ,鵞7D6xm6޼Kz[̗0w*7e#ˣ8B;9_4yd~6zC%cY7 -̨mIb9$:.޵zyi637(GBsFy?e& f[FopvQ1kMƺd)_fѰm ֶfˬ2f9pxG%Ok􎍳sVB<7js0en1(^k}"sbY ڱAc:]#(&˻Jbޕyۚ`,^@t|~Lhuy<]{#%v绤17o7K}߻f|}8e1[:(-cD,f@cu[ުw9zn˄w\le&v_vNkc=Jˎ!~y/3P3pO'|hܧAO=ғ9Q=zDHODZAʍnV{4o|*&·Xyb1*{ۓvC7 g{ϲΗ.V; K^fZޫ{w{5}xʫcw;ֹzw^t?nk߅f7.yL:xVu?W;{ֹֹz˾mn=ךwlI8D$c5# 6s@;ǝ+Ak+TGcioQkx0Nuޘ&9ͬnFyVmf3ȼwm|c M qMsZ;#$87P3'byp@ۨ7މoh~~}?1OCcxK|OHhdYqI޵7S!cjKDHsRpj1M9kuTw0vdD|{;dOK(BTcp0+,\mZ9DQ M1;qx` kyݪ;bj!b.W:UsVcnR[{<ݢ~ʳl@u)}8,Ż T{=vyg?}ު*sջ W5b?7MH{] -}OYhw1:k>YUuz 9jcU*;Gow?o~<]\@+u\[+Uunz.jzW3*+p,zmq?$]6uM=i'k὚2a;z{G~2a]ޮޞTgm-UX8bz5Uoջ܃}Mas[¾ֹza_{X\V=uz;3/ym[Ӧ}x'ڞw ඉzV#S;6&TqI Eh}M [&siFr2!hOUt`WWgrݙsByI-;ΌSoІt֓lt266unyqk Dgw>"fpӍC}RR,Tc5ҧj7FNzmR3oHEB>Yu.x! p@ m x!hBx@&@? m/)l@4@!B@"-6G m;7)l#/&Rh\I ^h\N)l mBA [m@xHa uB@+D [m/>CS H$$0O“?>ik$Xx? o 2wνh;,+||#|܆PN@/|nxV1>o7hϘ_Ż_ ܐ_(&<'HBKᏌBx.p/x;/Ë7/ sM᫃7?̿>p\.x ׆~5_tM+3qx*hvmJ^;#K/ |?}?<L?  Go 1OCc_? >E$o>r)|gb wb '{2}^?8I-x0IBl^88I-x%#  py؂+w /[/#/[pO\G9y~~D%)%"LhDT(0lasFlL'tVnV S4;j6]~WMzgt<^~q^sEYtQKeEY&`]e (\FeYEtQ.ʲEY(K-EYva/]%4`lei,-К.,]у.EYa]e8h(XMe tQIBetQ9KetQEXJe (˧.ʒ.ʲ,UkTW])ZEYZ]3EYz]eEY`8]e$FEYFc,]eEY&`]e*EYf`]eEY`]ej,+)]er(K-EYvIt&jC!5h[r#Zօo lk舓y3N|{8 ]mG86 ]|Wmu?\p'.0+%1ϮJ/jZN$w:?o5Nn1NgMۭY2ΎL~i'w{e χ'&]2<َO凬#q;9Ox?#yҺ'X9<94y.N`g<5;veMvKЍIɻ6.yK~ow%K?6!ЗxQ{&n$˽?,Cg5~:6||1,.#KVbRRm2TIRedXS2T ڻ,3\FD_bpR2Tl$npY*6,_,{,\F.#Ku^}edad.# `6X2 ,l}.# T6h2 ڸ,lS\FAOmp62 qYc\F=.# !m62 ^v6X/mPq6edaq_۠pYuIF/bp6/mp6/mp6q_mp8\FO,lű ^wY;cd3}ql.# `8>m\F ,l^繌,la׸,lű qY;c<2 s6xeda/mPqYXvuYű \FAjpG,l,l.# ۠8A?mp8.# F}ql]F,lű ^pYo8c2 /m6X/meda|/mR6qY8c2 Nu62 w62 u6eda/m߱86”t='rfAOs,KڬCr g^H^N+r{Eg}{x#"[w*yM}.? ?|_e+_w>Oߵ N_+Vgy\۞h;9rNطlۛβ 5HB|֪S'q1S+kDmvbǻxuwqXxuwx?=h3?z^rJGs6ċ8a~?sc_ qb/r7ϲ coS'#NKi~~Ql˻ǣ][٥ 'ű95C<cp;f#0|Tp;.5VEY_,tQ%x.^tQg1.2,}tQ;q+].r.\tQMe9 ],q"]EY0(aNY4`(ftQ#(r,7,%(l,tQwcCt&b.^E+~>$L<ǧ1:.qr,>.Ox(N _å7_ƻ?a@M;9qTő00^O"$K{3+gAO.o85 g^[~~~r:C:x[8-'.uijC8ɟ]c<يl&7-xgz il,blGN?/ơ>=,Hˡ*Fuiu& i}sB-tH6ߖJ:_֗V{K_rҚtwi]Zdz|*}n-}nw: yyQ.YK.KZ?#Tzw_kKu~"＀Y祗g iδҳ|>>}EKUR?;ҡg?ۇlUJ{oR*bo|s:kIavOu? ?H+lm+l, @_r]NZRXS4v9Y Fp9Y *lRVԺ,Xr)V,`R",p9Y y.'Kas0d)l:,Mr6]NFaRp q9Y\N6r]NASFv9Y $'Ka[]NAr%>u9Y5.'KaKdaw9Y 9.' `RLr9Y]NXm0d)j w9Yv.,l v.' ۠㾸ŽF#m7amP/5dapW؇Xr 8+5u9Y3$,l w,lю W,l! q[K96:GѺ'kaduNXd!fmvB򍵦A;~C-"m͓:kr"G%{Q5L.1 %^J 必oCZzGд;[w#˻~#mych]%t(o SkԆv~1Q.YYCpfy]絡/75/ ap&2#,0.rEYc]LL (GetQXFe (J䨥ln(K=B,iИ.-,mО.],=ї.2,C1.2,cp]eEY#tQNe,0.ʲ,PCe+,r+lUumFl67"V׆:[B)itCHRoapD+gM9knotOhևi]h{{KUi"""MMmsp9 Dcp "aEGA-#0FHAǨ1nNF,:AF!  8IUr=ӷSմ]uHkRd_u/^)wfv@Xr_z9-3k]oAAv`yۑ*oìMyovlyu+N{pTa1| @I>916| 槖372\%Ird6]N`ɒb,u9Y2+\NVA%Gɒٳxdrd6,-.'Kf۱dl7r9Y2 M2krd,u@'%rd6C]NFT%1rLr9Y2.' %Xrrd]NvG\N̞ij.' +.'Kfo-m%rv9Y2k@,dɬ :,]Nbn0d4q9Y u/. 1da7_\fanq~.' e(t9Y ^t/.WnqV`~q}v_\fda7_\f=da7_\f'4`~q paHsfŽɌ0. '6; 9a]N+I!vS8f"h~klK # ;>+ Q7tBg{(tChքpCh9Gc0'B+{:j? mOPBS{>\(eem[y9|K/O+ǕÎ+age}awE'+-71@eyEYc]Z:±c|Oh*|Vr; wò㮰<. ͗3%l/pCx/>~_30+l W>$"nBRJ:+;544RJ~-J Im<'jαSP:~UfQWUi6pyψRDZ̘6q~SUƏe1U_ZzƎJG*u+ ), (U=Tj|%O4\x5W̺hZ+>7i|j;5~NzFi?fύ|6JDž ̿ +5yZ_?곿n~ ϫKR G"tq, B{L '\AZx5W +R ,2ֺ,3< ødo\AZ,pwYjjtYjR\ 8dW Kof5iIAj+RV-tqY ں,]Av:WT؉+nWݠpY da7xda7xda7xda7da7da7da7da7da7da78da78da78da7 _! Aq8v=Q ű\Avp/ ű< n/n?_yaVĭ|z/{>_wV-9;xaAnMpMfǏ#ϊ{.x yZ,)iXF]xPƖ; ؁ّxsa>vL-E;Ǎ80~3vCNYrOYo3ilDLL,(˵GeY%tQeXAeY,k]tQ7.ʲ [,۰.WŦNYZ0(8. },0.ʒT(hL$(L(<,,tQXEeyEY3tQux.:ޤlFlb66B qs츭2mrNԍ+g̸ƽbCXgߊv6+O;A6!6uO-ھڤx鱝͌x$MŞUkbg.v6;v㼮>-/8]qo23V}#1'؃q}2{)YNg/,U{o,U{ ]J.%KնcKRRT-T̥dZ+q)Y\J@_j1ԥdډ8ͥdw)Yv.t)Y63\J]\Jbj.%KVbKRKnKRKnKR_`KRKnLRTz+ݠKRR v)Y6 ',c\J\Jv.%K.Õ.% |j76`KR!I^r)Y p/j_,[oKn_\bN\Jv6UHtv)Y &'X?znxgÒa6$n%#|>2l'%dι''CC}~F&}l&W?'i'ݤMĹ&߰%lJr]tI70/M:4\/|VڮNZCpsh7&-H Kl~PYܜ|YYma7%wT$;+$U'pmɖd۾Fl6f Le=EYtQ5x.r/EYa ]e!EY,(4LL(XAeɑEYHentQhOeitQM,_ƛNYv(fl~Aey ,/i(XCeEYc]V,ŵtQ+0.2,X(,6z_ >nI d&MIxc)u1ޒt&]}>?nH<=i뒃5Ix}ҌIHBR:)9dͧ/Mdo|.O3=EwG_΍bzlT:zԐRRRusa{UJ[}E}jwUeH#gL6cz6uQn|p#J]K=x?To(o$?ܗ ߽]koAȈB-:#rÌ1c1͘{$$GNr ##9ҿ/2ֻDiwg?ww=rYˢCA6dÀ\nF FKe;ڡ<-*,%%%>F.rC,cy\V "ω1!Ĉ_=ݞo%\#qu/^Ե("DD)D.E5 @W[|vwbv#vh &1Lb6N1\( daXBL4b# 7VG߯d3#ǧU7%!t~.8y} ̉G Q eƋɢIS#{{[*kUŝ*࿖[偓ۂXެ_Ǹ1,+;iӷ 0oaG۴W'ϭk=3B'6#sXp} iIބ씌3Z=jf_3ֲmF6JGی`ѢY;C IOH?{JV쌁ÂӒ$2=.wc4x]궞f&tt0f +3)PoFvRJ:mFxgW^ΝҽwFhOZ+0J(*7qH:͹sۭ7Tӻr(;̐t6غMJ׸YzkX?ׯt=Kz_l9OkҽȉvCw Rxݟ7؉gs[ ;hGn;}e9EFq2d<Y dOhNŬ8@'*'e #T2f5Qƪ8[>*ZƫH:"PيW>jbrU.jI-;vjo3zߚԋ0zdzQZ/(zKwN%gNB[Z/n<^CE+ d+U|J\⪫($#NEG("DY8 qNB9RDp0уY⎠= PW]=+wEyW(uubWGssQבּ9?5,Qܙf$x Âvx<-تo-&X_yϫ?0Vp]=1 LS 4LLBlPζXLm9^%9r*b r [D71 C0 p+f9Mh wN!ϛa@Bz0f~[YOߕڸ+v7o]=T*E-^⌌'eqB&c2 t'~~T0Gs'0I)M4y/i<`*t/6 >;1/ vr<\ӯ72*QcފwVZz/Ku6rOlFt+N;mSR_M|Xp3R9&rju^yDni@gHs3tUտݸY7zI`lfW*䗭i2r.\xkF<y2~>^]G?b4K[J. ]a9bނ~!oɥH.694yraC[Vȅr/7 I: Ʌri|4Gr i}`|ȿA*yt z{G)g.Բ]r&/9O/'A(0_˗_(sY U4]ABHF7rgk]stQ>K1`&&P 2Wt;EU`Cpi*n\V=EjȆ-S[%&DSJ{U 4ҡ0Z@RA dCD24S=h QKVqh㩕 ]?Cs7EJUo1y:n鬺RW 9\Iat= ]UuPA8PCA_O=xt$.\ 9V=A1#}ijFlՔ W-@KgZCa0A΄>C= ZBnarhƪFq! OT?%0tM /s = 3}yfZ y6W!nP^W 5ua7 ̀<]էW=.:&fL*F;]ZդlX `䥪-QJҼP!yT9PrEzlݬ*&UyɡDYDA\ :Hn:h>C{=U:'4IpZgQ.+5 \* .#繦}D>&8 Y}NU,38!c&sq\_NW0oD\GSTߊrЗs _)X4vp}-;{Owr24mWװ~9QλkphfW^#GݼV'3M.4A97@{>Mf^ex?]B^wExwEvطroC 9,7IAyy.tshϦ jj~7a_&f&Ϥ`:ϠWUOeœiu>8C\EΣ K A s4`O}Αq8K<^iQ` l~| i؟pM7!MoL2!C78Ada^}('IC'N %Pn Ga)P8B9~yqipozc@4("wQo {kb70@g t7?N@ o{#J 9E\}_Di ҔmAkȏRynEsK *U1ށ*iRsBMCD%Ԙ\ܘȇ@1 Cs3F- AtB$8 ŰS`O6iR-PPuwBWS8A5C_:crh LiU!RFQY*}At;Q% m<+ i Y@碕dQXc-`_G֒2/̢kB3~3 t:'^}, ߠb]G%b.GB3Έ8(t߉tDL}LoघL/,Κl\; 'F55#զY`+Ú3~ߵu` WɱGA7y#3L>f6s;1s;9f>A7W3 f*]gdJ\'>]\ J2>1K̗C) "wW x6g|7#ɷ?gMl_+~kѮ\s`Ms<ls s r3Н|NbN#4O`kv9{]~Ǯ`Esρ]k{S姩 w&wnM%<R"EY+DV]HF!\)B(h#Կ@^&Xƅְp뜞;tCoHpɧVި =Az ȇK9?\4hsӟ*U ^=cqjI*dϝڅpKbSzN< ;rS X5oMH7"R:N liHibPC!U#K5lX 4:!5D}ǯt؇/'\LdA69M9bȻvcȂLyCNz83z]&.!!%|y%0ӔQO0cb&aƀS3es8{~l+&+i8#>Z> W ""h"h+鉺K#cf > WU#\QCS=>ĚNuAMOx6VrW]Fsm+=m&} 66azc/M?q^jޤ^Ir=DCz;^q1rE;F8I͈ﰴ1|u_|+p>z#J/Ѱ6Ԫ8kZ[y!҈j/_aV&xy|Hx{1qʙsQgP1gD!&jک((MzѼ'E/9>K9KtfWKՎ5.XXlV+?%1W pTy+ld lǂ_RG )c {)r+_ȔɨLBL&4c8SYa!-EK;d*&xi5)n:ЪuϹ]]ik{;oνRq=.p{,q3\>Ь Qd2epV>C)߯\7oT/ײ-\' IN,EۑIߺ z6k{8!տT#֙ y]nlKZǽKx3f["ƑM;CqD ăf٥aKXw4pW5{z,᎔-Q$֋VT Sԋ-݉ăh_1dBJRmxZ7bS՘D[os"̟DDeH8EoL D%{nYiF=f ="s' J*׉X\wxMb,;Om;w|x(Yj^ߎtu=چoq쪐*` ܁:XКhi*DD{nK5h,0c32/Ao E߽KO2ց7!,\h\+3)D S#rH8%GI={(O2e='gfۦG 뫄mM2۱DE؈;[;eD+Zj%;UYk<sH+X,Wu,52[*MP8zybxB`1+m.f.`7cC3=`lĀ)njVVVSde`>:wsm\y xjx*kzG6&Po2qv/2 )nK:BoHNemZ$ױrYO/VBQ:GsW̑8jͰ< -Y{9Th iEvK#@tJ@WbhMq;4?w"7GPi7Gzù)M]֤=roq>|Բ3JѥwC@Y*+Vsh/O+l#ӶSq5Y?iIz#h*`z{PڧC/\+ -|F廇ҝ&ÜO|ʌy+fL-0U!3 `.͘xJJ1?133i`:ٌLe3Jgt&9,?h'>q$kO2̔4y<fрQhķ:.,L/CS`2WR`DY O98,%UC'/bw(tp0a!0!-6$ӆGI 5iQ`&  h<LUK 3l{HHRK)t[ªoa/ ,%wу] ݩQfUPɺoɢ Aӟ{}%rJkٽJl!ܓR)|Lwm#G%,جZ  !;LZ.Xd&bZSCev tDYm#G׻qDŚ! ʣJ$_.ʪ9_t$Jϩ֌YLO͘X}0aɠ_pgv#^jz=`׳7"Z lC/6l$λq|U\sb =[?%g +R/2= K\6Oq,@lɾM#hEFh%.ubx&Lۢ!%9me%SNgf3%8Sd0<,&Cl9nfx̌y տK݌i8O^3c1?f1,K+.Вxw0w5c&9e|> 3&=="k(yRSסU+#  Qv v}zXq5Q6& a;jwT͸0X Pܴ~'=.3OJ=`>EFtsվ8dQyR{vVy7pe6_9>h3?TVճC=FmOHFG4w&Lb7~ _jWU"5F5We0Vy݉1` x@mEHUE[6ɺfINUq|yf:`.,0cp`1G)ߌ{s<30m1wŸ1syer)Φj,Xe[P [L^%- c V2 $lأָx@fE-X1IrD`L2d"'jJm*3CRᆱZůw|Zצ=]lcjzUgP(sm$ۅ$"J<kjL宁owƵ݈kN|5c'egִZ5Qs]ՈLUȁjTKs[=}>3 TnՀB}W[?tg%Y zft Nέ<]_7yе 3[W!ױ>jPg/TH`[pݾhkAjzI7qKF96 ԗq\K]\?sz܉;;pqN&m+aGYQ{g{&gH L$2")^s;]o:e'Yx=vF`ƶ1 TW1f֎G`w1 =g1c)Q h VywO@JB2t>(lrSԂ5/ }-9l i&e"c@6_4L?-L##tCY'b'h& {Ӫ&Hj\^ʎ8*ԗvlC}\=׃hͅ]m&k7sG~74GL k#o[;~6_wSNb _'˔*6og[ke4K|^Jݟ7M{%@3;y[3q*6MfA6#OtJ6ϊPO㊭$a8NM|qx֨}nK_5 bcOnj+MjBWdtIT $Ϝ#8?V=($l&;fEJ)1|֦eT4ߜ,a:)TGJX=b"|uԟ=դOdE wmƹI_ǟo8YC>d~x}Wjb+7!)Rv38b;,-ɻoAl E8" lڂebAL^ԟؕzpa1~F~_״P͗bu+f%㨃grѐ'l(Rj#*eVzX /2T[XL,iX 1yv0C6 :eYL+V4S4luڼ,iA@,$ClŌ 6ok %`M+鋄zfE;k] 4crfVS.Ɗ!5Ia1~>hǼ̦csve`Va0R U}G>a< 1c^fy;0k sk 0^s+O&~I[(3+\>hyZfŶ_pTFy^_؂U3k֐9غڪۑSɪ[Q?3 r{94ZK1YtIy8fUɫ?(VY <+ꢡAQm'ǓF44ɪTVM?M2FMOff1yv)`N65+-Wi~㶒s{GG~,fVrDn8Ud O)wD53TKݬ(k͌h=kMѴT~73.ヒ>c/ujZH^6z&pQ׆}Lf}fqnc}0 k*1whzc{]̥ĵza23{!:Uj!ݯJu fwGU^62{ D+գCanb{+͎>ׁUkV} O96F(Dl_wpǟ7az~25&rJjM՘ZYWCWYIFt]C)fƝD_q0܅.2:ߧ _%9|&Иklǔbf`)jWlK; ~ӎ;_|͎RE`o1K$0oS{b |/{tg^c1<> d2VçrCtygCxQDҵ3 Xik0 WS5s'ݜcC~v}]ztղ#+ef*Gbֶvkؑ ^zuV'=W\w:˘|<G\wި1oOz*oq޶.99ZmN9'j G{Ӎw@}]Όp1;64ӭC>1N:XL0'׋pu|ϟF6lSs@΢RFin:ɞ%yYR]i| lcz)cƀ;u&QD~PέL*f΃RT, g<sO$b1fu V'qOr6sջߑ,`oJ·rr*@ r*\ٵd*1˅u{jJ W~& ^x-kg",hR/1- c8{xrO~\Uv{"*:y3Rt"GE:ڡP_z{ ў+ћAG8/\uԜ`h=mEUD.QL&WZ(=BPC=¿G+#d;N ;%$gt5SJOEkt/ڼ[tVOL `/F礫*_ ;ų2YNܭAV]ku╙ŒB%qMDXNFYhrޛ*(6`/S]nMԎNXݯs= .lY%n(3J q0XWzdjμfLBWٟG%/6qSY9!3BTb\19.1wnOK鎉ޛ #}<#cnCǏj˘Z˹qh_Ԅ|.4_Gi+0ZGzSGrB(D}q.<& jϷBoxT1#y:1ָQ&#N3|ǡh'Nw6aYW?Z@&Q0Zq-]kr%< +B!2_=;}Ǖ_9ijp\:A@jȁ $v;~91,`j"l&GmeҤс&e"8Pbg8vH7* !"#$%&'()*+,-./0123456789:;<=>?@ABDEFGHIKLMNOPQRSTUVWYZ[HwpSummaryInformation.CBinData  PrvImage PrvTextBIN0001.wmf /BIN0002.wmf6Section0a/<T ȴ l| \ DNA microarray, Array CGH, Tissue MicroarrayX i pt0 x  Developing a data model for integrative analysis of DNA microarray, array CGH and tissue microarray for cancer genomics research Hye Won Lee, M.S., Yu Rang Park, B.S., Jung Hoon Woo, B.S., Ju Han Kim, M.D. Ph.D. Seoul National University Biomedical Informatics (SNUBI), Seoul National University College of Medicine, Seoul 110-799, Korea, correspondence to juhan@snu.ac.kr Abstract: Cancer genomics studies using DNA microarray have been increased the utility of gene expression profiles to classify tumors into clinically relevant subtypes and predict prognosis of patients. Tissue Microarray (TMA) and array Comparative Genomics Hybridization (arrayCGH) technologies are used for identifying molecular markers from population-based analysis and analyzing genomic structure, respectively. Integration of clinical information and various biological data such as DNA microarray, arrayCGH, and TMA data is helpful to understand underlying biolog>GIF89atɻxxxkkk]]]PPPCCC555((( d`LH00`Hذ̘`H0|pdXL@`0H `H0`dHL`H0xp`XH@0d LȰ``HH00dLؘȀ`H0xp`XH@d0L `H0d`LH`H0|pdXL@0`$H`dHL00`HذȘdL0xp`XH@0` HdH0ȳ``HHdL0xp`XH@`0H Ը̰ĠऀؘpȈXxHp@h@d8`8X0xT0pH dxddxd`d`p`|``x`p``x`!,t H*\ȰÇ#JHŋ3jȱǏ CIɓ(S\ɲ˗0cʜI͔s'Ϝ~ tP==ХMuz4ѡVj}gׯQwKaQhE)m֤kIXo=k5ݿN*X5$X_XoWRWF8ٰi=1ᤎ1ŐYymg̃9Hb:iz=NUږ[%L>_Mcө?N9}><ﲿnmpz淾 ~l|7gۀ1 R_GߑW`A&a`Rم[Xpm߇ 睇7\Z8aZg]0`֛}&\]Ҙ1ycf_)`K_zQ` h$Qai'M /b9禓(]AUJ'cl%w{ b&^d]2Yn.ZtIgAbZP({xi* frXm3rSn]9yVJii`Za=భGVj)2*ɥ%Q荾 b+ea[ڨjnծ+xz+b\k߫Z`C G,eFԮZ\nVڒM *+{gl&Kܰ*ĬUᬛ/:zחGA)lp8F:Xn%֠u JĂ,mV mŒz̴VWqtq2d,xPW v^L+wݎu)7M䔗_ߍ.B=Bj es㏣;2/4(b>y mNR}g1'+鎳'!g{H.tɮz5WR4.h5 f WśH՝c5إ3[X՟ڭXرMJ7>lJH.Ida.%F2Ͱ;Yek qB 00 a[vI gK&*QopXA%s;ƌfB̾7NBˑ$;E uu!?8z628@ rha%LU~h|\ո}~ʟ-IW;$0d8|'#- /KIB |0,\ry,楎A.Tդ7 Ɩj w/?̐ߨVQL!76]#W=s D,c'i9=6'aBf0_'5!1q91 K$%ƁOYJ/HIIlswb{;^ˏ{ĄX.ϑKbRW=Yfv<Spy]Mo1Ȭ2kA7.)]?uKl^ccȪv9 sZߧgK&HWP Document FileWpe~~7,@H.j@Iz$Gh.%H4l$R&)o`n6$a971ݽC/7r0LbKmZ4OhjK/Y"lKޟ*fI;uKq }j{үSwޑ)ߺ z6k28#pBF/m{U^z*\n%-TO%J<spS"y#-ě7CY9*-ԙ"$?bnYV ĕpmǞ^K#qKg*Q'jD)A_5ueBFȻe@7,pU]oFj0Cc/7bnd?'l݊8UoLId%;ow4~3@bLDOdqU5Xk#,;-8'lXb;wHᚣzWvgY56cW|ZwppJQ k3ɞ٣7<z%Źgke^,x{ =df7!,\cAUlu9rCJ$QࣺY$nBJL{9yO>y`[̮g\"Klęʭ2|[#Z`dv-*?qTs1dzi5K Μ_wW RͧSwڣ:!Tݫ;\*$TgMt:ٿE2ŲVW+gjNO&1v^Z U*(ȉ&rɵ$7T{MvFNم3yB YQ[P:}ǢȨyf~cdF f7T{&:eRIG%nSn>ɣ^Ӛqcf/Y &|ڌy s3ƛFsf̝p\f.`r61#<cW1mbPW 2@ߺ:8yMjT5vNwJ8Q)N&Td >wͲ>e;}Y.[f-8x5{cq ̘5#~W=p};v+gSM: ,᎗Y2to9AwteWµ"upoOqGDwZb+?oN޳wW%"8 D]J_rD˘wbE8GpjFU]=v0N0HtF`Pg-GG~9< "8wYD%`$f=èIuu`pTCJzz'%`RRNR\#J aO;䪕wYNñWu "^cr@;<}55@9C(m=N!jPl1<9A_1jzɔEs6 *h/c$m| o6FQbEi ޕ<^_vlg{(W%=K>wTN7= :|{CvHo87wg9s=a74;8NÝ|?/2 'Ce8c.YdWp:qޏ1"06޵Y?đ&sτyoĽ-ǺNN#ޏNx FVwyp5,''zc,km3.nR?( M_dSLoC+lSAYV,A,Rε_iou&9GޏVITr.U}ZRYsG{q v@(p~^f[QHN˺O~F=EwR;;zs\>KNse>H)3`1uT̘76cNeVfx8 +S2j́3Ch ̘̊g3f0*#I_L`vn0d2hQ?q&kO*̔j7yшQh·z]9^J9NvUVʪ_7Sfa w{Zų3ӲDV{'2m2@"Vը_C:]R_4N_f{˂O:zJGthrrkiKni 3{Yyvdakd*"}}]eN.&6,&6$ӆdt(0a*_VIϒѮ&Tg1뀹8=ͥ!D&&-|a54&wbwSϣޛ#ָC'eKv7L}DݳeoHuS"%6Ih =\F[]k?rGZn35)kFN1GiٖHGf˹]j{ݟ;lo\X, 2 JTDFej-e7zXyJǙ"=UZbյAMa+Itjje} #E7šu7\A~xVJXmK?SRUI7bK֩~YQ8*ŝƇX%=~|(@y@ 1^+[o㨊b0 ɭJ$_PVWU+HGbU0{o̘U'19y܌b{fL0̘(0w1797l>0 3I`nʌ!ϰCre\ed/y/5c4=coD8dcA:Fֵo ёCjﻄ_z+\Y2w?_<d?:ZW >}tWۑߟ Sh^n+ku1ROwxnO$;X6Vi5폍.0lc\>_ܥ+\Sm3 C3= \6Ϝq<@lɾM+#hE?F؀%.bx&Lۢ!%9mNe%Sdf32r)K@es}gy&foy{70#fSmz]fLy&0'ˌ0KT/@Kfg1ߌ`M8|7̘gE!t+j w2jEka"<]zd dlPfQ)tW<-Җz>iWʽ wدroCT~V '蝙%`uHvs:IfƝ{ktQjQ/jp?}>q?pqWhM~ZV[hx_a@!<pW op1&w{*5" 8P`,V櫲0g"! =Rz6x C踧@?2>OxfL(Fy㗱q%R39{Z#~[f s;ޝ JdVdZTů Z-no!oT'X`ƔsaS ̆;͘nj9 LfL?0=̘17ǐȌyfd};.Ag!RMsf=*saRd6dL-r^f0q^5Q] ,r `akW&Џ2XآdWb&n32+hZRڕ+'{e'Cr!Ғ]]iu7w};g7BcؚPDɗ';SL.&N_fq){"jo mvL#05v7c=v0C1?; ;&CvCk;f/ۧ  o<+0Z‡U]/R滒H4˴he6)zrt՚9_dZ3JLz)GDǶlh$~"L##b:p m'h&!3*&H ԸqT0 vj;=C\=׃h˂YAS̵9d߼mh&i*~z[)wq H9?zi3[Ljcq=ovpCKJ]W:n)Nx,$ CF?% CrAbk{lSl' )HӢe#wyu޶'`ҏ19|ҎLhj 1osӎ9Lv`1fvLl?LnRu̞dTZ0eVh̡Ogбvwn]YI3PiD9ϓYⷉ5\1s{'ndR^s(ޣK S Kjqꦦ-'#(Ɓ:]?6E0ڔ0Jv#G'pFY|BYQ 78lYN:>zsWZ.5U3Czg@c*ݐڃ_%U6[fW^٨s7#Sf99rr~XF/= 5{LEn|c&v^`cǼL&:FKfCzv;quz WMDeLmZ_a`ӅI\<ǨXRs3ȼ?d3`MWT;\m^1{gͳcIlqXfpr~VCްEnM1y)| X( ōh|;9͌;;2݆W:䩜+:k8N+dJrјW9Zmr髦bAl 16qQMVP֭I?V\Fl-deǬIS)e?cڦL~yιз3sh4.Tob=Xc ?}SGv/ofL0~Sa_1C/}.4(!^0Pyrم%s7b}dK(UD|$ex2 &.ON>2s| }_Z-SŖX tTzuT륃F\8^2Kq4*G?|#o+LɅOR* }*]N,pE{?#jR!Ogq:ˊ@ ffmn!e5N6yN"dm1QptDCE3XJ"A1#ST78IƢ7qA*͘\)3=:e%I43z #ۈqDy tciv|]R o§Jp;Ө_{'-FU=[MC2'kօe>sʴ5UzL^+YZĆwVc8%*=*Ә${(e+6|ooMF3]T9cfr̾vr`~S LKv`>;dǼ 濱csv`b0R3 G9i< 1Uc^f;$0o s{Ȏ? y幝D'QsRj.KVU5q枳µ΋mXlMh/S%&."`-k&;ѐ9غڪӉ[~?3rC٭ͬ\RaR#YlYk*y'v5PӃ>Zm$V Ӥm1 2Mw*AGUf?%WˣvffvL ?s3IT UJfq[mp,fVr<ܦVId%O)39t0{+EF+fED7?^uqs4%*ÌK8yUnsr-PF/8""| /8jz/n6k3}QH?\7TCU5z\VmB_֠~UW@FWETM1c7AүT sw'vfYiF$JDQG rlFCl_Ttr7V+}~25&"xo[2~WcMԘ LhƎ L]s`F713Wv`[J`W%c)ww)>/ ޙܩ^k#VUqzydјlaNgJVv{Ν(G~Ϩj 94r]#K'Z Qڹ4`*?1N=tՕ瘉KTP?+}*GCd`=L*#n7YNJG>q%vcb`{ wą8x4l\®׻dfGn =kMjLaDzU7$]R9kUC2Q̸SkxhNM#I_=_ؗ[ڽ}w [2,E]mca|o1j0]o1ass߲cL;f0߱c@r`0֟B_WZmѳ}N gc̮U~ ]uQm/E$];*V_ʏ*hU;EpgbU&22"%zf*Gbֵv _L]v=tUhQ;23#Q" q~N0|76u{'X?|J'͓1ޭw𥀨 :.gtD:PExd8ڻY<9&nA=28qWczwˌ^Q?$M̼[dlFOGj-k#/ox ]<@S^+9+Q4YKzC&5ŸН jqK;zQ-Q9ݠPE_x*ܧ^b% z5]:ZAd~g↪ ـMXv\S3Į, 2BQqezpRtLr>3Fc1+pr"͎ƙcǼ{u +a9G;R'@Ѱ#7b ]&Ή:_8.{j:)Atd7b\"r NFo"ɟ:=R F$_5Z`Xv#"8f5givꙞ3EрzE\8ƱUqZkTS^U%w݅'[p>AT3p|W߱-Օ%* \\-Y6P.׾l2`>βh'0݋1Ď>9Pr[/u:%c-%WDE ?yM=5SP#H,׾DGMHϿQaPoU-]+C],V{5?:ʞ"- ߓr*?ZoRƉͷ^xp%If@yl%fN&#%vԎL݆ܣU%Tf`.c!zZ` ySnd|,Y)yh:W?Pƛ Ƒpx75[dpʳ#FDws,:dTw9'cvUj`9Ko Uoϙ\t#}wW7۳$ )H8Jl~PC/˜) d'.ė*`%,֓.jB\IDJP0 PZ]Kz=iwx?MyM7EA@ b9ɕŁ ľ˜0b5l62lxkiKmSD2(13;Jm