ࡱ> ^mRoot Entry୔B9a!FileHeader\DocInfoHBodyText WB9`B9_` !"#$%&'()*+,-.01246789:;<=>3bcdefghijkl/opqrstuvwxyz{|}~Root EntryP&8!FileHeader\DocInfoHBodyText 8p483 / !"#$%&'()*+,-.01246789:;<=>@ABCDEFGHIJKLMNOPQRSTUVWXYZ[\]HwpSummaryInformation.ABinData p48p48PrvImage 2PrvText !"#$%&'()*+,-./0123456789:;<=>?@BCDEFGIJKLMNOPQRSTUVWXYZ[]^_abcdefghijklmnopqrstuvwxyz{|}~I. <1 D tǩ\ Ȑ i 0X ȹtl\t ̸  Gene Set-Wise Analysis of Microarray Data Using Principal Component Analysis Sung Bum Cho M.D. M.S.1, Tae Su Chung PhD.1,2, Ju Han Kim M.D., PhD.1,2* 1Seoul National University Biomedical Informatics (SNUBI), 2Human Genome Research Institute, College of Medicine, Seoul National University, Seoul 110-799, Korea, csb1749@snu.ac.kr, *correspondence to juhan@snu.ac.kr Abstract: Gene set-wise analysis provided many researchers a powerful way to understand microarray data. Correlation between gene set members, however, can confuse the gene set-wise testing procedure. In this analysis, the authors performed principal component analysis(PCA) of each gene set to avoid possible disturbing effect of highly correlated gene set members. The resulting orthogonal property of principal components can remedy the high correlation between gene set members. Global test was used for gene set-wise analysis. 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Correlation between gene set members, however, can confuse the gene set-wise testing procedure. In this analysis, the authors performed principal component analysis(PCA) of each gene set to avoid possible disturbing effect of highly correlated gene set members. The resulting orthogonal property of principal components can remedy the high correlation between gene set members. Global test was used for gene set-wise analysis. 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