ࡱ> Root EntryRoot Entry6@/FileHeaderYDocInfoKLBodyText\606 ) !"#$%&'(*,-./0123456789:;<=>?@ABCDEFGHIJHwpSummaryInformation.DBinData 0606PrvImage PrvText !"#$%&'()*+,-./0123456789:;<=>?@ABCEFGHIJLMNOPQRSTUVWXZ[\^_`abcdefghijklmnopqrstuvwxyz{|}~<tDž pt0 iD \ i  Complex trait analysis with heterogeneous data integration Jung Hoon Woo, B.S.1,3, Eun Jee Lee, B.S.1, Ju Han Kim M.D., Ph.D.2,3* 1Interdisciplinary Program in Bioinformatics, Seoul National University, 2Seoul National University Biomedical Informatics (SNUBI), 3Human Genome Research Institute, Seoul National University College of Medicine, Seoul 110-799, Korea *correspondence to juhan@snu.ac.kr Abstract: A key object of biomedical research is to elucidate the complex gene interactions underlying complex traits such as common human disease. Recently 'genetical genomics approach' that use microarray expression data to measure the influence of genetic variation on gene expression has been established. Such an integration of the two heterogeneous genomic data have offered different perspective on complex trait analysis. In this research, we developed a multistep methodology with applying set-wise genetical genomics approach to uncovers polygenic interaction of complex trait. 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